CTBP1
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Official Full Name
C-terminal binding protein 1 -
Overview
CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene act -
Synonyms
CTBP1;C-terminal binding protein 1;C-terminal-binding protein 1;BARS;brefeldin A ribosylated substrate;brefeldin A-ribosylated substrate;MGC104684
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Chicken
- Zebrafish
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- E. coli
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CTBP1 involved in several pathways and played different roles in them. We selected most pathways CTBP1 participated on our site, such as Chronic myeloid leukemia,Deactivation of the beta-catenin transactivating complex,Degradation of beta-catenin by the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | NFKB1,CRKL,HDAC2,STAT5B,CBL,CCND1,MAP2K1,BRAF,RAF1,SHC2 |
| Notch-mediated HES/HEY network | GATA1,GATA6,RCAN1,MYOD1,HES6,TLE1,MYB,HEY1,YY1,ASCL1 |
| Deactivation of the beta-catenin transactivating complex | SOX4B,TLE3,BCL9L,PYGO1,CBY1,PYGO2,SOX6,SOX32,C,BCL9 |
| Degradation of beta-catenin by the destruction complex | FAM123B,TLE3,AES,CTBP2,TLE3B,TLE2,TLE4,TLE1 |
| Disease | SSRP1,TLR10,KERA,CTDP1,CDK9,KPNA4,CDK8,FDXR,TH1L,GCKR |
| Diseases of signal transduction | TNKS,CUX1,CPSF6,RNF43,LRRFIP1,RBP1,DERL2,MIB1,FKBP1A,RLBP1 |
| Notch signaling pathway | PSENEN,DLB,PSEN2,SNW1,MIB1,MFAP2,LFNG,KAT2A,CTBP2,NUMBL |
Protein Function
CTBP1 has several biochemical functions, for example, NAD binding,NADH binding,RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTBP1 itself. We selected most functions CTBP1 had, and list some proteins which have the same functions with CTBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | PLAUR,SERPINB1A,LAMP1,CNOT1,TUBA1A,HIST1H4L,PHRF1,YWHAB,VCP,GSN |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HMGCRB,UEVLD,HSD3B5,CTBP2,GPD1,LDHBB,SDR42E1,HSD3B6,LDHBA,FAM213B |
| transcription factor activity, sequence-specific DNA binding | ZNF571,MYT1LA,KAT7,FOXO1B,DLX2,SMAD6A,SALL1A,PIP4K2AA,POUV,RHOXF1 |
| transcription factor binding | HDAC9,ZEB1,MYOCD,TFDP2,ARNT,ADD1,IFI16,PBX2,DDIT3,PURB |
| NAD binding | HSD3B5,PHGDH,AOX3L1,UGDH,GPD1B,ME1,GAPDH,TESCA,CYB5R3,IDH3A |
| protein binding | PSMD11,ULK2,GATA4,ZNF490,SMG9,ERAL1,TAP1,S100A16,PLCB4,SRA1 |
| protein C-terminus binding | KCNIP3,SIRT1,MAP3K7,C11orf60,PABPC1,AP2A1,MED12,YAP1,FIGN,ZBTB16 |
| RNA polymerase II transcription corepressor activity | TFAP2B,HDAC1,RERE,N4BP2L2,TXLNB,SOX3,TLE1,BEND6,SIN3B,UXT |
| protein homodimerization activity | KIF20B,PDCD10,TSC2,TYR,GRIK2,DCK,MIXL1,PRLR,ALDH1A3,MTMR2 |
Interacting Protein
CTBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTBP1.
HIC1;ZNF366;e1a_ade05;RBBP8;CTBP2;EBNA6;KLF4
CTBP1 Related Signal Pathway
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