CST4
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Official Full Name
cystatin S -
Overview
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function. -
Synonyms
CST4;cystatin S;cystatin-S;Cystatin 4;Cystatin S precursor;Cystatin SA III;Cystatin-4;Cystatin-SA-III;CYTS_HUMAN;MGC71923;Salivary acidic protein 1;OTTHUMP00000030443
Recombinant Proteins
- Human
- Bacillus subtilis
- Streptomyces coelicolor A3(2)
- Rat
- Staphylococcus
- HEK293
- Wheat Germ
- Insect Cell
- E.coli
- E. coli or Yeast
- Mammalian Cell
- Human Cell
- Mouse
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CST4 involved in several pathways and played different roles in them. We selected most pathways CST4 participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salivary secretion | PLCB2,RYR3,LPO,ITPR3,PRB1,CALM1,PRKCA,ATP1B2,FXYD2,CAMP |
Protein Function
CST4 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CST4 itself. We selected most functions CST4 had, and list some proteins which have the same functions with CST4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase inhibitor activity | CSTL1,CARD18,CST9L,SERPINB4,CST3,CST14B.1,NGP,AHSG1,BIRC5A,BIRC5B |
Interacting Protein
CST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CST4.
SOD2;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
Resources
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References
- Zhang, Q; Zhao, XZ; et al. Expression and purification of soluble human cystatin C in Escherichia coli with maltose-binding protein as a soluble partner. PROTEIN EXPRESSION AND PURIFICATION 104:14-19(2014).
- Fine, JD; Bruckner-Tuderman, L; et al. Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 70:1103-1126(2014).
