CRYGB
-
Official Full Name
CRYGB crystallin, gamma B [ Homo sapiens ] -
Overview
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. -
Synonyms
CRGB_HUMAN;Crygb;Gamma-B-crystallin;Gamma-crystallin 1-2;Gamma-crystallin B;crystallin, gamma B
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CRYGB involved in several pathways and played different roles in them. We selected most pathways CRYGB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRYGB has several biochemical functions, for example, structural constituent of eye lens. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYGB itself. We selected most functions CRYGB had, and list some proteins which have the same functions with CRYGB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of eye lens | CRYBB1,LIM2.5,CRYBB3,LIM2.2,LIM2,CRYGN1,VIM,CRYABB,CRYGN2,CRYBB2 |
Interacting Protein
CRYGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYGB here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYGB.
Resources
Related Services
Related Products
References
- Roberts, CJ; Blanco, MA; et al. Role of Anisotropic Interactions for Proteins and Patchy Nanoparticles. JOURNAL OF PHYSICAL CHEMISTRY B 118:12599-12611(2014).
- Moreno-Mendieta, SA; Guillen, D; et al. A novel antigen-carrier system: The Mycobacterium tuberculosis Acr protein carried by raw starch microparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS 474:241-248(2014).
