CREG1
-
Official Full Name
cellular repressor of E1A-stimulated genes 1 -
Overview
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. -
Synonyms
CREG1;cellular repressor of E1A-stimulated genes 1;cellular repressor of E1A stimulated genes , CREG;protein CREG1;CREG
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Mammalian cells
- Wheat Germ
- E.coli
- Human Cell
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Fc
- Non
- Flag
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CREG1 involved in several pathways and played different roles in them. We selected most pathways CREG1 participated on our site, such as Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Senescence and Autophagy | IFI16,IGFBP7,MAP1LC3B,AMBRA1,FKBP8,IL24,ING1,SLC39A2,ING2,UVRAG |
Protein Function
CREG1 has several biochemical functions, for example, FMN binding,oxidoreductase activity,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CREG1 itself. We selected most functions CREG1 had, and list some proteins which have the same functions with CREG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FMN binding | NOS2B,NOS1,PNPO,NOS3,TYW1B,POR,CREG2,NDOR1,HAO1,TYW1 |
| oxidoreductase activity | TDO2B,QDPRA,AOC1,RDH14A,RDH10B,CYP2F2,CYP2K19,GMPR2,HSD11B1L,CYP3A5 |
| transcription corepressor activity | SIAH2,LOXL2,SUFU,NFIL3,TBL1XR1A,JAZF1,ALX1,SKOR1B,DDX54,TGIF1 |
| transcription factor binding | TBL1X,HDAC7,HES6,PIM1,NKX2-5,IGHMBP2,PSMC5,CRY1,PARD6A,DAXX |
Interacting Protein
CREG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREG1.
purT;glyA
Resources
Related Services
Related Products
References
- Yan, CH; Li, Y; et al. CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:353-364(2015).
- Peng, CF; Han, YL; et al. OVEREXPRESSING CELLULAR REPRESSOR OF E1A-STIMULATED GENES PROMOTE HYPOXIA-INDUCED VEGF PARACRINE VIA HIF-1 IN MESENCHYMAL STEM CELLS. HEART 99:E24-E24(2013).
