CREB3
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Official Full Name
cAMP responsive element binding protein 3 -
Overview
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined. -
Synonyms
CREB3;cAMP responsive element binding protein 3;cAMP responsive element binding protein 3 (luman);cyclic AMP-responsive element-binding protein 3;Luman;LZIP;CREB-3;basic leucine zipper protein;transcription factor LZIP-alpha;cAMP-responsive eleme
Recombinant Proteins
- Rhesus macaque
- Human
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CREB3-1020R | Recombinant Rhesus monkey CREB3 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CREB3-1842H | Recombinant Human CREB3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CREB3-396HCL | Recombinant Human CREB3 cell lysate | Human | Non |
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| CREB3-2261HF | Recombinant Full Length Human CREB3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 371 amino acids |
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| CREB3-845R | Recombinant Rhesus Macaque CREB3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CREB3-845R-B | Recombinant Rhesus Macaque CREB3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RFL11908HF | Recombinant Full Length Human Cyclic Amp-Responsive Element-Binding Protein 3(Creb3) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-395) |
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Involved Pathway
CREB3 involved in several pathways and played different roles in them. We selected most pathways CREB3 participated on our site, such as AMPK signaling pathway,Adrenergic signaling in cardiomyocytes,Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | NRAS,HIST1H3A,HIST1H2AL,ATF6B,PPP1CA,HIST1H2BL,GM14482,SLC18A2,CAMKK2,HIST1H2BH |
| AMPK signaling pathway | LEPR,IRS1,PRKAA1,PFKP,PIK3R3,HMGCR,LIPE,RAB10,CPT1B,CCNA1 |
| Adrenergic signaling in cardiomyocytes | ATP1B2A,PPP1CAA,RAPGEF3,ADRa1A,ATP1A1B,CACNB3A,KCNQ1,MAPK3,TPM4B,ATP1B1 |
| Cocaine addiction | GRM2,BDNF,CREB5,RGS9,ATF4,MAOA,CREB3L4,CREB3L1,PRKACG,DDC |
| Cholinergic synapse | KCNJ4,PIK3CD,PLCB2,KCNJ6,CREB3L3,CHRM4,GNB3,KCNJ14,FOS,MAPK1 |
| Aldosterone synthesis and secretion | STAR,AKR1C1,LDLR,PRKCG,HSD3B2,PRKACA,LIPE,PRKCB,HSD3B5,PDE2A |
| Dopaminergic synapse | ITPR1,KIF5B,CREB3L4,PPP1CB,PRKACB,GNG2,PRKCA,PPP3CA,MAPK8,GNAI2 |
Protein Function
CREB3 has several biochemical functions, for example, CCR1 chemokine receptor binding,DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB3 itself. We selected most functions CREB3 had, and list some proteins which have the same functions with CREB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | TFAP2B,ACTN2,NCOA2,FIGLA,DAO1,DNM1,MYCLB,TCF23,BTRC,TXLNB |
| chromatin binding | SIRT6,PRMT6,SOX10,SSRP1,L3MBTL1,SIRT7,EOMES,SFPQ,WHSC1,SMAD6 |
| CCR1 chemokine receptor binding | CCL5,CCL23,CCL3,CCL4,CCL7 |
| transcription factor activity, sequence-specific DNA binding | TEAD1A,BLZF1,BCL3,BARX1,RFX5,TCF19,FOXB1A,TBX22,BATF3,SIM1B |
| protein homodimerization activity | HSP90AA1,SYT14,CITED1,ABP1,HINT2,PLD6,CLIC6,ABAT,NLRC4,GREM2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MYF5,AKNA,TFAP4,TFE3A,HNRNPK,NCOA2,HIST2H3A,ELK3,CC2D1B,FEZF2 |
| cAMP response element binding protein binding | CRTC3,CREM,CRTC2,DAPK3,DDIT3,ATF2,CRTC1,CRTC1A,KCNA3 |
| DNA binding | TBX2A,ZNF143B,ZNF224,ZNF524,HOXA1A,ERCC2,MGMT,SPATA24,NR5A2,RARB |
| cAMP response element binding | CREB3L3,CREB3L4,CREB1,E4F1,JUN,CREB3L3A,HMGA2,ATF6B,ATF2,CREB3L1 |
Interacting Protein
CREB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB3.
HCFC1;STX8;JUN;DDIT3;NFIL3;CREB3L3;BATF3;CREBZF;CREB3L4;10431
CREB3 Related Signal Pathway
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References
- Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
- Kawarabayashi, Y; Hai, L; et al. Critical Role of TRPC1-Mediated Ca2+ Entry in Decidualization of Human Endometrial Stromal Cells. MOLECULAR ENDOCRINOLOGY 26:846-858(2012).
