CPZ
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Official Full Name
carboxypeptidase Z -
Overview
Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ) is a typical antipsychotic. Chlorpromazine works on a variety of receptors in the central nervous system, producing anticholinergic, antidopaminergic, antihistaminic, and weak antiadrenergic effects. Both the clinical indications and side effect profile of CPZ are determined by this broad action: its anticholinergic properties cause constipation, sedation, and hypotension, and help relieve nausea. It also has anxiolytic (anxiety-relieving) properties. Its antidopaminergic properties can cause extrapyramidal symptoms such as akathisia (restlessness, aka the 'largactil shuffle' where the patient walks almost constantly, despite having nowhere to go due to mandatory confinement, and takes small, shuffling steps) and dystonia. It is known to cause tardive dyskinesia, which can be irreversible. -
Synonyms
CPZ;carboxypeptidase Z;metallocarboxypeptidase Z;MGC99682
Recombinant Proteins
- Human
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CPZ-11548H | Recombinant Human CPZ, His-tagged | E.coli | Human | His | 303-652a.a. | |
| CPZ-1581R | Recombinant Rat CPZ Protein | Mammalian Cell | Rat | His |
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| CPZ-6147C | Recombinant Chicken CPZ | Mammalian Cell | Chicken | His |
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| CPZ-7296HCL | Recombinant Human CPZ 293 Cell Lysate | HEK293 | Human | Non |
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| CPZ-1238R | Recombinant Rat CPZ Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CPZ-1238R-B | Recombinant Rat CPZ Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CPZ-2251H | Recombinant Human CPZ Protein (Met425-Tyr652), N-His tagged | E.coli | Human | His | Met425-Tyr652 |
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Involved Pathway
CPZ involved in several pathways and played different roles in them. We selected most pathways CPZ participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CPZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CPZ has several biochemical functions, for example, metallocarboxypeptidase activity,serine-type carboxypeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPZ itself. We selected most functions CPZ had, and list some proteins which have the same functions with CPZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallocarboxypeptidase activity | CPO,CPM,CPB1,AGBL5,AGBL2,CPN1,CPA5,AGBL1,FOLH1,CPA2 |
| serine-type carboxypeptidase activity | CPVL,SCPEP1,DPP7,PRCP,CPDB,CTSA,CPN1,SENP2,CPM,CPE |
| zinc ion binding | CXXC1B,MLL5,MLLT6,TRIM58,MICALL2A,ESRRGB,TTF2,ERI2,LANCL1,NEIL2 |
Interacting Protein
CPZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPZ here. Most of them are supplied by our site. Hope this information will be useful for your research of CPZ.
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References
- Yamasaki, T; Suzuki, A; et al. Comparison of the Anti-Prion Mechanism of Four Different Anti-Prion Compounds, Anti-PrP Monoclonal Antibody 44B1, Pentosan Polysulfate, Chlorpromazine, and U18666A, in Prion-Infected Mouse Neuroblastoma Cells. PLOS ONE 9:-(2014).
- Xu, HY; Yang, HJ; et al. Differential effects of antipsychotics on the development of rat oligodendrocyte precursor cells exposed to cuprizone. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 264:121-129(2014).
