CPSF1
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Official Full Name
cleavage and polyadenylation specific factor 1, 160kDa -
Overview
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime;processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to;facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and;Manley, 1995 (PubMed 7590244)). -
Synonyms
CPSF1;cleavage and polyadenylation specific factor 1, 160kDa;cleavage and polyadenylation specific factor 1, 160kD subunit;cleavage and polyadenylation specificity factor subunit 1;Cleavage and polyadenylation specificity factor 160 kDa subunit;CPSF 160 kDa subunit;CPSF160;HSU37012;P/cl.18;polyadenylation specificity factor
Recombinant Proteins
- Rhesus macaque
- Mouse
- Zebrafish
- Human
- Mammalian Cell
- E.coli
- HEK293
- His
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CPSF1-1008R | Recombinant Rhesus monkey CPSF1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CPSF1-3858M | Recombinant Mouse CPSF1 Protein | Mammalian Cell | Mouse | His |
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| CPSF1-6460Z | Recombinant Zebrafish CPSF1 | Mammalian Cell | Zebrafish | His |
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| CPSF1-1667H | Recombinant Human CPSF1 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Leu300 |
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| CPSF1-1942M | Recombinant Mouse CPSF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CPSF1-1942M-B | Recombinant Mouse CPSF1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CPSF1-833R | Recombinant Rhesus Macaque CPSF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CPSF1-833R-B | Recombinant Rhesus Macaque CPSF1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CPSF1 involved in several pathways and played different roles in them. We selected most pathways CPSF1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | EIF4A3,PPP2R5D,GSPT1,HBS1L,SMG1,SMG7,PPP1CBL,PCF11,pab1,PPP2R3C |
Protein Function
CPSF1 has several biochemical functions, for example, RNA binding,enzyme binding,mRNA 3-UTR AU-rich region binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPSF1 itself. We selected most functions CPSF1 had, and list some proteins which have the same functions with CPSF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | DDX17,KIN,NHP2L1A,DUSP11,NOL9,THOC3,ADAD2,RBM27,LIN28A,CAPRIN2 |
| mRNA 3-UTR AU-rich region binding | ZFP36,CPEB3,CPEB2,CPEB1B,ELAVL1,CPEB1 |
| enzyme binding | STUB1,GSTM3,TP53,SORT1,TSPAN15,ADORA2A,HSPA8,HIST1H2AE,ZFHX3,PDCD2 |
| nucleic acid binding | ZFPM2A,ZNF740,IMPDH1,ZFP458,ZXDC,SSX1,BRD9,ZNF740B,SCRT1,GIN1 |
Interacting Protein
CPSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPSF1.
Ywhae
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