CPOX
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Official Full Name
coproporphyrinogen oxidase -
Overview
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP). -
Synonyms
CPOX;coproporphyrinogen oxidase;coproporphyrinogen oxidase (coproporphyria, harderoporphyria) , CPO;coproporphyrinogen-III oxidase, mitochondrial;coproporphyria;CPX;HCP;COX;coprogen oxidase;coproporphyrinogenase;CPO
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CPOX-1570R | Recombinant Rat CPOX Protein | Mammalian Cell | Rat | His |
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| CPOX-1807H | Recombinant Human CPOX Protein, GST-tagged | Wheat Germ | Human | GST |
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| CPOX-3723Z | Recombinant Zebrafish CPOX | Mammalian Cell | Zebrafish | His |
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| CPOX-3855M | Recombinant Mouse CPOX Protein | Mammalian Cell | Mouse | His |
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| CPOX-527H | Recombinant Human coproporphyrinogen oxidase, His-tagged | E.coli | Human | His | 111-454 a.a. |
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| CPOX-1227R | Recombinant Rat CPOX Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CPOX-1227R-B | Recombinant Rat CPOX Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CPOX-1939M | Recombinant Mouse CPOX Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CPOX-1939M-B | Recombinant Mouse CPOX Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CPOX-2107HF | Recombinant Full Length Human CPOX Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 454 amino acids |
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Involved Pathway
CPOX involved in several pathways and played different roles in them. We selected most pathways CPOX participated on our site, such as Heme Biosynthesis,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPOX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Porphyrin and chlorophyll metabolism | EARS2,UGT1A7C,UGT2A3,COX10,BLVRB,UGT5G1,UGT2A1,CP,UGT1AB,UGT1A7 |
| Metabolism | SLC25A21,AMD2,MED10,AGPAT6,AK8,CYP4F11,GSTK1,ISCU,TYMP,CA5B |
| Heme biosynthesis | COX10,COX15 |
| Metabolism of porphyrins | UGT1B1,UGT1B7,UGT1B2,COX10,UGT1B3,UGT1B5,COX15,UGT1B4 |
| Metabolic pathways | GART,TKT,RIMKLA,DHCR7,CYP2C37,ALP3,DGAT2,POLR2J3,INPP5L,NDUFA8 |
Protein Function
CPOX has several biochemical functions, for example, coproporphyrinogen oxidase activity,protein homodimerization activity,structural constituent of eye lens. Some of the functions are cooperated with other proteins, some of the functions could acted by CPOX itself. We selected most functions CPOX had, and list some proteins which have the same functions with CPOX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of eye lens | BFSP1,CRYBB3,CRYAA,LIM2.1,ATXN1,LIM2,LIM2.3,HSPB6,CRYBA1,MIP |
| protein homodimerization activity | SNX9,DDX1,STC2,MCL1,PYGB,MIXL1,OLFM4,PEX7,FZD1,ADAM10 |
| coproporphyrinogen oxidase activity | RSAD1 |
Interacting Protein
CPOX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPOX here. Most of them are supplied by our site. Hope this information will be useful for your research of CPOX.
UBE2G2;2_aha_camp;8-aha-camp;8-aha-omethyladenosine;Fech;Cpox;Slc25a4;Ppox;Slc25a5;Vdac2;Abcb7;Glrx5;Slc25a11;Abcb10
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