CPNE1
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Official Full Name
copine I -
Overview
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. -
Synonyms
CPNE1;copine I;copine-1;CPN1;Copine 1;Copine1;CopineI;COPN 1;COPN1;CPN 1;CPNE 1;MGC1142;OTTHUMP00000030775;OTTHUMP00000030776;OTTHUMP00000030778;OTTHUMP00000030784;OTTHUMP00000196688;OTTHUMP00000199602;OTTHUMP00000204169
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- Insect Cells
- In Vitro Cell Free System
- HEK293T
- HEK293
- GST
- His
- Non
- SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CPNE1 involved in several pathways and played different roles in them. We selected most pathways CPNE1 participated on our site, such as Glycerophospholipid biosynthesis,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPNE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | CKM,ST3GAL3A,GGT6,PNP5B,AMD2,HS3ST4,GLYAT,SUMF2,ACY3.2,TPH2 |
| Glycerophospholipid biosynthesis | ABHD4,AWAT2,ABHD3,PITPNB,CPNE3,AWAT1,CEPT1A,PHOSPHO1,STIL,PNPLA8 |
| Metabolism of lipids and lipoproteins | FAM213B,ACOT6,MED9,LPA,YAP1,NFYBB,APOBB.1,NFYBA,APOEB,Alb |
| Phospholipid metabolism | ABHD4,PLBD1,PLD6,PTPMT1,CEPT1A,CPNE3,SACM1LA,ARF3,SACM1LB,ABHD3 |
Protein Function
CPNE1 has several biochemical functions, for example, NF-kappaB binding,calcium ion binding,calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPNE1 itself. We selected most functions CPNE1 had, and list some proteins which have the same functions with CPNE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LHFPL5,ABI2,FAM117B,NLRP2,UBE2R2,POGK,MAPK9,RGS1,HIP1R,CKS1B |
| endopeptidase activity | PSMB2,PSMA4,PSMA6,ACE2,KLK1B22,TPP2,KLK1B11,KLK1B8,HTRA4,APH1B |
| calcium ion binding | CASQ1,NOTCH3,PCDH1G9,SYTL3,LTBP3,LALBA,MYL1,ZFP652,CALML5,SPTA1 |
| calcium-dependent phospholipid binding | ANXA1B,ANXA3,SYT9,PLA2G4A,SYT11A,ANXA4,ANXA5,ANXA1A,SYT3,DOC2B |
| protein homodimerization activity | MID2,CACYBP,PRTFDC1,TERF1,IDH1,SNX1,KYNU,TCF3A,CD8A,RAB11FIP4 |
| NF-kappaB binding | CDK5RAP3,COMMD7,ANXA4,MTDH,TAF4B,DNAJA3,PSMA6,ANKRD42,NFKBIA,HSPA6 |
| phosphatidylserine binding | OSBPL10,PLCD1,AP1S2,ANXA13,SYT4,RPE65,AXL,GAS6,ANXA9,GAP43 |
| transporter activity | CRABP1B,ABCG2,SLC23A2,SEC14L2,SYPL1,SLC6A20B,SLC15A5,TMEM184A,LCN12,AQP9B |
Interacting Protein
CPNE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPNE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPNE1.
YWHAZ;UIMC1;BUB3;STK3;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;pi3p;FN1;ARRB2
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