CPB2
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Official Full Name
carboxypeptidase B2 (plasma) -
Overview
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] -
Synonyms
CPB2;carboxypeptidase B2 (plasma);CPU;PCPB;TAFI;carboxypeptidase B2;carboxypeptidase R;carboxypeptidase B-like protein;thrombin-activable fibrinolysis inhibitor;thrombin-activatable fibrinolysis inhibitor;carboxypeptidase B2 (plasma, carboxypeptidase U)
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- HEK293
- Human
- Mammalian Cell
- Wheat Germ
- E.coli
- Human Cell
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- Non
- GST
- His&S
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CPB2 involved in several pathways and played different roles in them. We selected most pathways CPB2 participated on our site, such as Complement and Coagulation Cascades,Metabolism of Angiotensinogen to Angiotensins,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | PROC,C1R,CFD,SERPING1,C8A,F13A1,C1QB,SERPINE1,C4A,C1QC |
| Metabolism of Angiotensinogen to Angiotensins | CTSG,ATP6AP2,CPA3,CPB1,ACE,CMA1,GZMH |
| Protein digestion and absorption | CPB1,DPP4,SLC3A2,CELA2A,KCNK5,CPA2,ATP1B1,ATP1A2,SLC7A8,COL13A1 |
| Pancreatic secretion | CTRB1,PLA2G2A,ATP1B4,PNLIPRP1,ATP1B2,PRKCA,KCNQ1,Slc4a2,TPCN2,CELA3B |
| Metabolism of proteins | MUC12,MIA3,DCP2,TBCB,NAPG,NAT8B,EEF1D,YIF1A,CKAP4,TRAPPC1 |
| Peptide hormone metabolism | GRP,CPB1,SPCS3,CPE,ACE,INHBAA,RAB27A,CDX2,DPP4,GZMH |
Protein Function
CPB2 has several biochemical functions, for example, metallocarboxypeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPB2 itself. We selected most functions CPB2 had, and list some proteins which have the same functions with CPB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | DPF2L,PJA1,ADAM2,TRIM58,DBF4,UQCRC1,FHL1,BMI1B,USP45,ADAMTS20 |
| metallocarboxypeptidase activity | CPN1,AGBL1,FOLH1,AEBP1,CPO,CPA1,CPDB,CPA4,CPA3,CPE |
Interacting Protein
CPB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPB2.
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References
- Allaart, JG; van Asten, AJAM; et al. Beta2 toxin is not involved in in vitro cell cytotoxicity caused by human and porcine cpb2-harbouring Clostridium perfringens. VETERINARY MICROBIOLOGY 171:132-138(2014).
- Kircanski, J; Hodgins, D; et al. Development of an antigen-capture enzyme-linked immunosorbent assay for Clostridium perfringens beta2-toxin in porcine feces and the neonatal piglet intestine. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION 24:895-902(2012).
