COX18
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Official Full Name
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae) -
Overview
COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of;the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the;assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 (PubMed 16212937)). -
Synonyms
COX18;COX18 cytochrome c oxidase assembly homolog (S. cerevisiae);mitochondrial inner membrane protein COX18;FLJ38991;COII;COX2;COX2_HUMAN;COXII;Cytochrome c oxidase II;Cytochrome c oxidase polypeptide II;Cytochrome c oxidase subunit 2;MS405;MS419;MT CO2;MT-CO2;MTCO2;Cox18Hs1 protein;Cox18Hs2 protein;Cox18Hs3 protein;OTTHUMP00000160366;OTTHUMP00000219030;mitochondrial COX18;cytochrome c oxidase assembly protein 18;COX18HS
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COX18-11489H | Recombinant Human COX18, GST-tagged | E.coli | Human | GST | 187-333a.a. | |
| COX18-1740H | Recombinant Human COX18 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COX18-3811M | Recombinant Mouse COX18 Protein | Mammalian Cell | Mouse | His |
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| COX18-1912M | Recombinant Mouse COX18 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COX18-1912M-B | Recombinant Mouse COX18 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COX18-2001HF | Recombinant Full Length Human COX18 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 333 amino acids |
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| RFL1417MF | Recombinant Full Length Mouse Mitochondrial Inner Membrane Protein Cox18(Cox18) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (64-331) |
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Involved Pathway
COX18 involved in several pathways and played different roles in them. We selected most pathways COX18 participated on our site, such as Gene Expression,Generic Transcription Pathway,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| The citric acid (TCA) cycle and respiratory electron transport | COX14,LRPPRC,MPC1,NDUFAF7,TIMMDC1,SLC25A27,TACO1,PDK3,NDUFAF4,COX16 |
| Respiratory electron transport | NDUFAF7,TIMMDC1,SCO1,COX11,LRPPRC,C20orf7,NDUFAF6,COX14,TACO1,ETFB |
| TP53 Regulates Metabolic Genes | SCO1,TACO1,COX16,LRPPRC,FAM36A,SESN3,PRDX2,SURF1,COX14 |
| Metabolism | CTHL,NUDT16,CYP11B1,LMF1,BSG,SURF1,ELA2,CRAT,COX16,SLC25A10 |
| Gene Expression | TARBP2,ZNF567,ZNF223,ZNF180,ZNF486,MED15,ZNF786,EEF1G,TAF1C,LSM6 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | SLC25A27,COX14,NDUFAF5,C2orf56,NDUFAF4,NDUFAF3,NDUFAF6,SCO1,LRPPRC,SURF1 |
| Transcriptional Regulation by TP53 | PRDX2,COX14,TACO1,COX16,SESN3,FAM36A |
| Generic Transcription Pathway | ZNF331,NR6A1A,ZNF227,ZNF37A,ZNF549,KRBA1,NR4A2A,SKIA,FAM36A,NR1D2 |
Protein Function
COX18 has several biochemical functions, for example, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX18 itself. We selected most functions COX18 had, and list some proteins which have the same functions with COX18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein transporter activity | IPO13,SNUPN,L7RN6,KPNA7,AP4S1,AP1S3B,TNPO2,ARFGAP3,RAB4A,AP1G2 |
Interacting Protein
COX18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX18 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX18.
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References
- Vandell, AG; McDonough, CW; et al. Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study. JOURNAL OF INTERNAL MEDICINE 276:486-497(2014).
- Goncalves, VF; Zai, CC; et al. A Hypothesis-Driven Association Study of 28 Nuclear-Encoded Mitochondrial Genes with Antipsychotic-Induced Weight Gain in Schizophrenia. NEUROPSYCHOPHARMACOLOGY 39:1347-1354(2014).
