CORO1A
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Official Full Name
coronin, actin binding protein, 1A -
Overview
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. -
Synonyms
CORO1A;coronin, actin binding protein, 1A;coronin-1A;Clabp TACO;coronin 1;HCORO1;p57;clipin-A;coronin-1;coronin-like protein A;coronin-like protein p57;tryptophan aspartate-containing coat protein;TACO;CLABP;CLIPINA;FLJ41407;MGC117380
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- E.coli
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Flag
- His&T7
- Myc&DDK
Involved Pathway
CORO1A involved in several pathways and played different roles in them. We selected most pathways CORO1A participated on our site, such as Phagosome,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CORO1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | CTSSA,ABCB3L1,ATP6V1E1,cgr2b,C3,ATP6V0A2B,ITGB3,TUBB5,VAMP3,CALR3B |
| Tuberculosis | AKT2,MRC2,IL1A,MAPK8,IFNA1,ATP6V0D2,PPP3CB,RELA,IRAK1,MAPK9 |
Protein Function
CORO1A has several biochemical functions, for example, actin binding,actin filament binding,actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CORO1A itself. We selected most functions CORO1A had, and list some proteins which have the same functions with CORO1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NOL4,TRIM31,KBTBD7,VLDLR,CTR9,RNF180,FUS,SCAF8,JAM2A,PAM |
| poly(A) RNA binding | NSUN5,SLBP,KRR1,EIF3G,KTN1,PUM1,LRP1,CSNK1E,MRPS9,RPS24 |
| actin monomer binding | TWF1,PFN1,COBLL1,ABL1,TMSB4X,NOS3,LIMA1,KLHL8,LMOD3,MKL1 |
| protein homodimerization activity | USH2A,ACTN1,CRYBA2,KIF20B,SLC14A2,KCNE2,ADRB2,HAND1,ADD2,DMRTC1C2 |
| actin filament binding | MACF1,SVILA,HAND2,CORO2A,FLNA,MYO7A,MYO1A,MTSS1,DBNL,GAS2L2 |
| actin binding | WASH1,TNNT2A,MYBPC2,FMNL2,LRRK2,MICAL2B,FXYD5,FMN2,DAAM1B,PHACTR4 |
| protein C-terminus binding | PRKAA1,ATP2A2,PFKM,PHB,XRCC5,VAMP2,KCNK3,VGLL3,NPAT,CTGF |
| phosphatidylinositol 3-kinase binding | INSR,PIK3R1,TYRO3,PDGFRB,IGF1RB,IRS2,LCK,HCST,IRS1,CALM3 |
| myosin heavy chain binding | MYBPC3,MYL9,AMPD1,MYL12B,MYL2,PDLIM2 |
Interacting Protein
CORO1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CORO1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CORO1A.
FSD2;GOLGA2;STAT3;DKK1;UBE2G2;POLR1C;LMO2;MAGOH;SMAD3;FHL3;GIT2;TAB1;tuf;glpA;spoVR
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References
- Xu, XJ; Tang, YM; et al. ZCH-2B8a, an antibody targeting actin-binding protein coronin-1a, is a potential therapeutic agent for B-lineage malignancies. JOURNAL OF DRUG TARGETING 22:488-497(2014).
- Eitzen, G; Lo, AN; et al. Proteomic analysis of secretagogue-stimulated neutrophils implicates a role for actin and actin-interacting proteins in Rac2-mediated granule exocytosis. PROTEOME SCIENCE 9:-(2011).
- Ahmed, Z; Shaw, G; et al. Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 55:687-700(2007).
