COQ3
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Official Full Name
coenzyme Q3 homolog, methyltransferase -
Overview
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both;eukaryotes and prokaryotes (Jonassen and Clarke, 2000 (PubMed 10777520)). This lipid consists of a hydrophobic;isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to;anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the;respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic;pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic;acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene;product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl;phenol. -
Synonyms
COQ3;coenzyme Q3 homolog, methyltransferase (S. cerevisiae);coenzyme Q3 homolog, methyltransferase (yeast);hexaprenyldihydroxybenzoate methyltransferase, mitochondrial;bA9819.1;polyprenyldihydroxybenzoate methyltransferase;DHHB-MT;DHHB-MTase;DHHB
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COQ3-1538R | Recombinant Rat COQ3 Protein | Mammalian Cell | Rat | His |
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| COQ3-1715H | Recombinant Human COQ3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COQ3-733Z | Recombinant Zebrafish COQ3 | Mammalian Cell | Zebrafish | His |
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| COQ3-7348HCL | Recombinant Human COQ3 293 Cell Lysate | HEK293 | Human | Non |
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| COQ3-1195R | Recombinant Rat COQ3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| COQ3-1195R-B | Recombinant Rat COQ3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| COQ3-1974HF | Recombinant Full Length Human COQ3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 369 amino acids |
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| Coq3-2269M | Recombinant Mouse Coq3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| COQ3-5716H | Recombinant Human COQ3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
COQ3 involved in several pathways and played different roles in them. We selected most pathways COQ3 participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COQ3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | SLC27A5,CYP2A12,ackA,AGXT2L1,AGMAT,ODC1,SEPHS2,ADH1,ALDH18A1,POLR3A |
| Ubiquinone and other terpenoid-quinone biosynthesis | COQ7,COQ5,AMOTL1,HPDB,HPD,HPDA,VKORC1,GGCX,VKORC1L1,COQ6 |
Protein Function
COQ3 has several biochemical functions, for example, 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity,3-demethylubiquinone-9 3-O-methyltransferase activity,O-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COQ3 itself. We selected most functions COQ3 had, and list some proteins which have the same functions with COQ3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity | PRDM12,PRDM13,FBLL1,PRMT8B,METTL21D,METTL23,FAM86,TRMT10C,TRMT10B,PRDM11 |
| O-methyltransferase activity | TOMT,METTL7B,ASMT,DIMT1,COMT,FBLL1,NDUFAF5,PRDM11,PRDM12,RNMTL1A |
Interacting Protein
COQ3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COQ3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COQ3.
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