COQ2
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Official Full Name
coenzyme Q2 homolog, prenyltransferase (yeast) -
Overview
This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. -
Synonyms
COQ2;coenzyme Q2 homolog, prenyltransferase (yeast);4-hydroxybenzoate polyprenyltransferase, mitochondrial;4 hydroxybenzoate polyprenyltransferase;CL640;FLJ26072;MGC91278;2310002F18Rik;FLJ13014;hCOQ2;MGC124824;OTTMUSP00000032111;Para-hydroxybenzoate--polyprenyltransferase, mitochondrial;PHB:polyprenyltransferase;RGD1306722;COQ2 homolog;para-hydroxybenzoate-polyprenyltransferase, mitochondrial
Recombinant Proteins
- Rat
- Human
- Mouse
- Zebrafish
- Mus musculus
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COQ2-1537R | Recombinant Rat COQ2 Protein | Mammalian Cell | Rat | His |
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| COQ2-1713H | Recombinant Human COQ2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COQ2-3790M | Recombinant Mouse COQ2 Protein | Mammalian Cell | Mouse | His |
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| COQ2-5589Z | Recombinant Zebrafish COQ2 | Mammalian Cell | Zebrafish | His |
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| COQ2-1194R | Recombinant Rat COQ2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| COQ2-1194R-B | Recombinant Rat COQ2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| COQ2-1897M | Recombinant Mouse COQ2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COQ2-1897M-B | Recombinant Mouse COQ2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COQ2-1973HF | Recombinant Full Length Human COQ2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 371 amino acids |
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| RFL5960MF | Recombinant Full Length Mouse 4-Hydroxybenzoate Polyprenyltransferase, Mitochondrial(Coq2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (35-374) |
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Involved Pathway
COQ2 involved in several pathways and played different roles in them. We selected most pathways COQ2 participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COQ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquinone and other terpenoid-quinone biosynthesis | COQ6,TAT,VKORC1L1,HPDA,VKORC1,COQ7,COQ5,HPD,HPDB,COQ3 |
| Metabolic pathways | KHK,PMM2,PPAP2C,HEXA,POLR3K,AMT,LIPC,MAOB,FUT9,MGAT5B |
Protein Function
COQ2 has several biochemical functions, for example, 4-hydroxybenzoate decaprenyltransferase activity,4-hydroxybenzoate nonaprenyltransferase activity,prenyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COQ2 itself. We selected most functions COQ2 had, and list some proteins which have the same functions with COQ2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity | UGT5A4,BMPR1AB,CMPK,SAT1A.2,NTRK3A,TNK2B,TPMT.1,PRKAB1B,FUT9B,MOCOS |
| prenyltransferase activity | PTAR1,PGGT1B,UBIAD1 |
Interacting Protein
COQ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COQ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COQ2.
Resources
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References
- Lin, CH; Lin, HI; et al. COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population. NEUROBIOLOGY OF AGING 36:-(2015).
- Desbats, MA; Lunardi, G; et al. Genetic bases and clinical manifestations of coenzyme Q(10) (CoQ(10)) deficiency. JOURNAL OF INHERITED METABOLIC DISEASE 38:145-156(2015).
