COMMD1

  • Official Full Name

    copper metabolism (Murr1) domain containing 1

  • Overview

    COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al.,;2005 (PubMed 16267171)).

  • Synonyms

    COMMD1;copper metabolism (Murr1) domain containing 1;C2orf5, chromosome 2 open reading frame 5 (MURR1);COMM domain-containing protein 1;copper metabolism gene MURR1;MGC27155;MURR1;C2orf5;COMD1;COMD1_HUMAN;copper metabolism domain containing 1;Protein Murr1;OTTHUMP00000159817

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Wheat Germ
  • E.coli
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • GST
  • His
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
COMMD1-1674H Recombinant Human COMMD1 Protein, GST-tagged Wheat Germ Human GST
COMMD1-2732H Recombinant Human COMMD1, His-tagged E.coli Human His
COMMD1-28013TH Recombinant Human COMMD1, His-tagged E.coli Human His 190 amino acids
COMMD1-28014TH Recombinant Human COMMD1, His-tagged E.coli Human His 190 amino acids
COMMD1-4265Z Recombinant Zebrafish COMMD1 Mammalian Cell Zebrafish His
COMMD1-7373HCL Recombinant Human COMMD1 293 Cell Lysate HEK293 Human Non
COMMD1-2213HF Recombinant Full Length Human COMMD1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 190 amino acids
Commd1-2246M Recombinant Mouse Commd1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
COMMD1-4633H Recombinant Human COMMD1 protein, GST-tagged E.coli Human GST 1-190aa
COMMD1-954H Recombinant Human COMMD1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    COMMD1 involved in several pathways and played different roles in them. We selected most pathways COMMD1 participated on our site, such as TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMMD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF-alpha/NF-kB Signaling Pathway DDX3X,TRAIP,PDCD2,NKIRAS1,SMARCE1,PEG3,CAPN3,TXLNA,CRADD,COPS3

    Protein Function

    COMMD1 has several biochemical functions, for example, copper ion binding,identical protein binding,phosphatidic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COMMD1 itself. We selected most functions COMMD1 had, and list some proteins which have the same functions with COMMD1. You can find most of the proteins on our site.

    Function Related Protein
    phosphatidylinositol-4,5-bisphosphate binding PLCB1,RPH3A,TWF2,ACTN2,FAM123B,RS1,FAM21C,KLHL8,SLC9A1,KCNJ2
    copper ion binding TRP53,SNAI3,LOXL1,LOXL2,LOXL5A,F5,S100U,ABP1,LOXL2A,PARK7
    protein binding CCDC86,TLDC2,SH2D2A,MRC1,KBTBD7,GLYAT,TLE2,TEKT3,GOLPH3L,C1orf187
    phosphatidylinositol-3,5-bisphosphate binding WIPI2,FAM21C,JPH2,SESTD1,WDR45,GBF1,WDR45B,WIPI1,PHLDA3,D6WSU116E
    identical protein binding SFRP1,IFIT3,CBLL1,MTSS1,UHRF1,E2F7,APPL1,DYNLRB1,FNBP1,ESR1
    phosphatidylinositol-3,4-bisphosphate binding MAPKAP1,GAB2,TTPA,SESTD1,RAG2,AKT1,PLEKHA1,KIF16B,PLEK,RS1
    phosphatidic acid binding PLCD1,MICALL1,MARK1,PACSIN2,SESTD1,MAPKAP1,NRGN,UQCC3,JPH2,RAPGEF6
    phosphatidylinositol-3,4,5-trisphosphate binding PIRT,PARD3,ADAP2,NRGN,OGT,D6WSU116E,RAG2,FERMT2,ZFYVE1,ARAP1
    protein homodimerization activity CARM1,S100A10,GM5506,CHMP4A,TRIM5,NR6A1A,NR4A3,LGALS1,GCA,HOMER2

    Interacting Protein

    COMMD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMMD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COMMD1.

    COMMD6;CCDC22

    Resources

    Research Area

    Post-translational Modification of NFkB/IkB

    References

    • Phillips-Krawczak, CA; Singla, A; et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. MOLECULAR BIOLOGY OF THE CELL 26:91-103(2015).
    • Li, HY; Burstein, E; et al. COMMD1 regulates inflammation and colitis-associated cancer progression. ONCOIMMUNOLOGY 3:-(2014).

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