COL4A2
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Official Full Name
collagen, type IV, alpha 2 -
Overview
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. -
Synonyms
COL4A2;collagen, type IV, alpha 2;collagen alpha-2(IV) chain;canstatin;collagen type IV alpha 2;DKFZp686I14213;FLJ22259;ICH;POREN2
Recombinant Proteins
- Chicken
- Human
- Mouse
- Mammalian Cells
- Insect Cells
- E.coli
- Yeast
- His
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL4A2-3965C | Recombinant Chicken COL4A2 | Mammalian Cells | Chicken | His |
|
|
| COL4A2-1263H | Recombinant Human COL4A2 protein, His-tagged | Insect Cells | Human | His | 1261-1712aa |
|
| COL4A2-1765H | Recombinant Human COL4A2 Protein (Gly1441-Ala1669), N-His tagged | E.coli | Human | His | Gly1441-Ala1669 |
|
| COL4A2-2327M | Recombinant Mouse COL4A2 Protein (1481-1707 aa), His-sumostar-tagged | Yeast | Mouse | His&SUMO | 1481-1707 aa |
|
| COL4A2-2373M | Recombinant Mouse COL4A2 Protein (1481-1707 aa), His-tagged | E.coli | Mouse | His | 1481-1707 aa |
|
| COL4A2-2714H | Recombinant Human COL4A2 protein, His-tagged | E.coli | Human | His | 1493-1712aa |
|
| COL4A2-335H | Recombinant Human COL4A2 Protein, His-tagged | E.coli | Human | His | Ser1487~Ser1703 |
|
Involved Pathway
COL4A2 involved in several pathways and played different roles in them. We selected most pathways COL4A2 participated on our site, such as Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | CAPN2B,ACTN2,ITGB3B,THBS3A,ITGAV,COL24A1,ITGB5,PPP1CAB,LAMB4,MYLK2 |
| ECM-receptor interaction | LAMB2,ITGB6,ITGB1,CD36,COL6A2,GP5,ITGA3B,COL1A1B,ITGA1,THBS1 |
Protein Function
COL4A2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A2 itself. We selected most functions COL4A2 had, and list some proteins which have the same functions with COL4A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
COL4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A2.
Resources
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References
- Seidl, C; Port, M; et al. Differential gene expression triggered by highly cytotoxic alpha-Emitter-immunoconjugates in gastric cancer cells. INVESTIGATIONAL NEW DRUGS 28:49-60(2010).
- Poschl, E; Schlotzer-Schrehardt, U; et al. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. DEVELOPMENT 131:1619-1628(2004).
