COL27A1
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Official Full Name
COL27A1 collagen, type XXVII, alpha 1 [ Homo sapiens ] -
Overview
Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form major structural elements in extracellular matrices of cartilage, skin, and tendon (Boot-Handford et al., 2003 [PubMed 12766169]). -
Synonyms
collagen, type XXVII, alpha 1;KIAA1870;FLJ11895;MGC11337;collagen alpha-1(XXVII) chain;COL27A1
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL27A1-11431H | Recombinant Human COL27A1, GST-tagged | E.coli | Human | GST | 54-381a.a. | |
| COL27A1-1520R | Recombinant Rat COL27A1 Protein | Mammalian Cell | Rat | His |
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| COL27A1-3731M | Recombinant Mouse COL27A1 Protein | Mammalian Cell | Mouse | His |
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| COL27A1-1177R | Recombinant Rat COL27A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| COL27A1-1177R-B | Recombinant Rat COL27A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| COL27A1-1859M | Recombinant Mouse COL27A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COL27A1-1859M-B | Recombinant Mouse COL27A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
COL27A1 involved in several pathways and played different roles in them. We selected most pathways COL27A1 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL27A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | COL21A1,SLC8A1,ELN,COL6A4,CTRL,CELA3A,PRSS3,CPA2,SLC3A2,XPNPEP2 |
| Focal adhesion | ARHGAP5,PTK2AA,PPP1CC,STYK1,CAV3,SRC,ROCK1,COL11A2,SRMS,TESK2 |
| ECM-receptor interaction | LAMB3,VTN,ITGB4,ITGB3B,SDC1,LAMA3,Itga10&Itgb1,ITGA7,COL2A1B,ITGB1B.2 |
| Amoebiasis | Itgam&Itgb2,SERPINB1B,VCL,IL6,CSF2,GNA15,ITGAM,RELA,LAMB3,PLCB2 |
| Platelet activation | FYN,MYL12B,GNAI2,STIM1,GP5,PLCB3,PIK3R1,PLA2G4D,GUCY1B3,FGB |
| PIK-Akt signaling pathway | PTK2,IL6,DDIT4,GNGT2,EIF4E2,GNG12,ITGB8,IFNA2,MTOR,RPS6KB1 |
Protein Function
COL27A1 has several biochemical functions, for example, extracellular matrix structural constituent,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL27A1 itself. We selected most functions COL27A1 had, and list some proteins which have the same functions with COL27A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | TGFBR1,AMDHD2,TRIM35-19,CYP21A1,POLB,RAF1B,ADPRM,TRIM35-28,ZNF547,ZIC3 |
| extracellular matrix structural constituent | COL24A1,COL5A1,COL8A2,COL4A4,MUC5AC,ELNA,MGP,FBN1,OPTC,COL5A3B |
Interacting Protein
COL27A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL27A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL27A1.
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References
- Gonzaga-Jauregui, C; Gamble, CN; et al. Mutations in COL27A1 cause Steel syndrome and suggest a founder mutation effect in the Puerto Rican population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:342-346(2015).
- Scharf, JM; Yu, D; et al. Genome-wide association study of Tourette's syndrome. MOLECULAR PSYCHIATRY 18:721-728(2013).
