COL25A1
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Official Full Name
collagen, type XXV, alpha 1 -
Overview
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded;protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer;amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of;over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded;protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different;isoforms have been found for this gene. -
Synonyms
COL25A1;collagen, type XXV, alpha 1;collagen alpha-1(XXV) chain;alzheimer disease amyloid-associated protein;collagenous Alzheimer amyloid plaque component;collagen-like Alzheimer amyloid plaque component;AMY;CLAC;CLACP;CLAC-P
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL25A1-11430H | Recombinant Human COL25A1, His-tagged | E.coli | Human | His | C-term-332a.a. | |
| COL25A1-1644H | Recombinant Human COL25A1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COL25A1-7377HCL | Recombinant Human COL25A1 293 Cell Lysate | HEK293 | Human | Non |
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| COL25A1-2096HF | Recombinant Full Length Human COL25A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 496 amino acids |
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Involved Pathway
COL25A1 involved in several pathways and played different roles in them. We selected most pathways COL25A1 participated on our site, such as Collagen biosynthesis and modifying enzymes,Collagen degradation,Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL25A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collagen formation | COL8A1A,TLL1,COL4A4,CTSS,COL6A1,COL9A1A,COL17A1A,LOXL1,COL15A1B,DST |
| Degradation of the extracellular matrix | MMP12,TPSAB1,TIMP2B,CTS7,CTSL2,ACAN,ADAMTS8,MGC174155,MMP17,ADAM8A |
| Extracellular matrix organization | BSG,CTSB,PCOLCEB,COL5A2,F11R.2,MMP8,FAM49BA,TLL1,P3H2,COL17A1 |
| Collagen biosynthesis and modifying enzymes | COL4A6,COL28A1D,COL15A1B,COL13A1,COL3A1,COL9A3,COL5A3B,BMP1,COL17A1,PCOLCE |
| Collagen degradation | CTSD,ADAM10,CTSK,COL23A1,MMP19,MMP15,MMP10,LOC100686744,CTSL1,MGC174155 |
Protein Function
COL25A1 has several biochemical functions, for example, beta-amyloid binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL25A1 itself. We selected most functions COL25A1 had, and list some proteins which have the same functions with COL25A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-amyloid binding | HSD17B10,CHRNA7,CD74,GPRASP2,APBA3,TM2D1,BACE2,NGFR,APBB3,TSSK1B |
| heparin binding | THBS2,ADAMTSL5,APOA5,PTPRF,ITGAM,VEGFB,WISP1,LXN,NAV2,THBS3 |
Interacting Protein
COL25A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL25A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL25A1.
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