COL10A1
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Official Full Name
collagen, type X, alpha 1 -
Overview
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). -
Synonyms
COL10A1;collagen, type X, alpha 1;collagen alpha-1(X) chain;collagen X, alpha-1 polypeptide;Schmid metaphyseal chondrodysplasia<br/>
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Bovine
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
COL10A1 involved in several pathways and played different roles in them. We selected most pathways COL10A1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures,Collagen biosynthesis and modifying enzymes,Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL10A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | ATP1A2,SLC3A1,ATP1A4,SLC8A1,ELN,COL7A1,SLC1A1,COL6A6,LOC780933,CELA2B |
| Endochondral Ossification | MMP13,SOX5,CDKN1C,FRZB,ADAMTS1,CTSL2,NKX3.2,ADAMTS4,COL2A1,CST5 |
| Extracellular matrix organization | COL10A1A,COL2A1,COL9A1B,BMP10,DDR1,COL4A5,TRAPPC4,COL5A1,ADAMTS5,CEACAM8 |
| Collagen biosynthesis and modifying enzymes | PCOLCEA,COL2A1,COL11A1B,PPIB,COL28A1D,PCOLCE,PRP,COL6A3,COL4A4,COL9A3 |
| Senescence and Autophagy | GABARAP,RSL1D1,UVRAG,RB1CC1,ING2,SLC39A1,ATG7,MAP1LC3C,SLC39A2,ING1 |
| Assembly of collagen fibrils and other multimeric structures | COL6A3,CD151,LOX,LOXL2,CTSL1,LOXL1,PCOLCE,COL5A3A,MMP20,COL4A3 |
| Collagen formation | LOX,COL23A1,COL11A1B,SERPINH1B,COL8A1,COL6A3,COL16A1,CTSS,COL5A3A,TLDC2 |
Protein Function
COL10A1 has several biochemical functions, for example, metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL10A1 itself. We selected most functions COL10A1 had, and list some proteins which have the same functions with COL10A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | Raet1c,MRTO4,OCRL,GET4,TUBGCP4,THRAP3,Akap3,SMIM3,GPR37L1,FGFR1OP2 |
| metal ion binding | KLF15,PTGS1,S100A10A,C1GALT1B,PFKP,ENPP5,ACAP3,ASXL2,PDP2,ZNF707 |
Interacting Protein
COL10A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL10A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL10A1.
BANP;UBQLN1;UBQLN1;P4HB
Resources
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References
- Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
- Alaseem, AM; Madiraju, P; et al. Naproxen Induces Type X Collagen Expression in Human Bone-Marrow-Derived Mesenchymal Stem Cells Through the Upregulation of 5-Lipoxygenase. Tissue Engineering Part A 21:234-245(2015).
