COBRA1
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Official Full Name
cofactor of BRCA1 -
Overview
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or;NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a;heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA;polymerase II (see MIM 180660) (Narita et al., 2003 (PubMed 12612062)). -
Synonyms
COBRA1;cofactor of BRCA1;negative elongation factor B;KIAA1182;NELF B;A730008L03Rik;AB041607;DKFZp586B0519;AI663983;Negative elongation factor protein B;NELFB;RGD1307832;RP13-122B23.3;RP23-132N23.4;NELF-B
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COBRA1-1618H | Recombinant Human COBRA1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COBRA1-377HCL | Recombinant Human COBRA1 cell lysate | Human | Non |
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| COBRA1-2006HF | Recombinant Full Length Human COBRA1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 475 amino acids |
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Involved Pathway
COBRA1 involved in several pathways and played different roles in them. We selected most pathways COBRA1 participated on our site, such as Abortive elongation of HIV-1 transcript in the absence of Tat,Disease,Formation of HIV elongation complex in the absence of HIV Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with COBRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of the Early Elongation Complex | TH1L,WHSC2,SUPT4H1,SUPT5H,CTDP1,GM3258,RDBP,NELFE |
| Abortive elongation of HIV-1 transcript in the absence of Tat | CTDP1,SUPT4H1,WHSC2,TH1L,RDBP,SUPT5H |
| Formation of HIV elongation complex in the absence of HIV Tat | CDK9,RDBP,SUPT5H,SSRP1,TH1L,SUPT4H1,ELL,WHSC2,TCEB3,PSTPIP2 |
| Formation of the HIV-1 Early Elongation Complex | SUPT4H1,TH1L,CTDP1,WHSC2,RDBP,SUPT5H |
| Disease | SUPT4H1,TTR,HEYL,IPO5,CPSF4,AP2A1,AMN,FDX1L,HMGA1,OPN1LW |
| Formation of RNA Pol II elongation complex | CCNT2B,CDK9,PSTPIP2,RDBP,ELL,NELFE,TCEB3,WHSC2,SSRP1,CCNT2A |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | ELL,TCEA1,RDBP,TCEB3,WHSC2,CDK9,CTDP1,TH1L,SUPT4H1,SUPT5H |
| Gene Expression | ZNF10,ZNF37A,ZNF434,USP9X,GTF3C5,CSTF3,SNAPC1A,ZNF624,ZNF256,MED20 |
Protein Function
COBRA1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COBRA1 itself. We selected most functions COBRA1 had, and list some proteins which have the same functions with COBRA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DCAF8,DIXDC1,EIF4A1,EDNRB,LUZP4,CYB5R1,LRRFIP1,IQCE,WDTC1,CRK |
Interacting Protein
COBRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COBRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COBRA1.
NELFE;BRCA1;NELFA;DENR;KHDRBS3;MGST1;HSPA9
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