CNKSR1
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Official Full Name
connector enhancer of kinase suppressor of Ras 1 -
Overview
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. -
Synonyms
CNKSR1;connector enhancer of kinase suppressor of Ras 1;CNK;CNK1;KSR;CNK homolog protein 1;Connector enhancer of KSR like;Connector enhancer of KSR1;hCNK1;connector enhancer of KSR 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CNKSR1-11686Z | Recombinant Zebrafish CNKSR1 | Mammalian Cell | Zebrafish | His |
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| CNKSR1-1562H | Recombinant Human CNKSR1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CNKSR1-373HCL | Recombinant Human CNKSR1 cell lysate | Human | Non |
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| CNKSR1-1926HF | Recombinant Full Length Human CNKSR1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 720 amino acids |
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Involved Pathway
CNKSR1 involved in several pathways and played different roles in them. We selected most pathways CNKSR1 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNKSR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 signaling | KLB,NRG4,PAQR3A,CSF2RA,SPTBN2,GRAP2B,AGO2,PHB,RASGRP1,SPTB |
| Downstream signaling of activated FGFR1 | MARK3,RASGRP4,KBTBD7,PEA15,DAB2IPB,IL17RD,SPTA1,AGO2,PTPRA,PAQR3B |
| ARMS-mediated activation | FGF10B,SPRED1,SPTBN1,CSF2RB,SLC14A2,AKAP9,DUSP6,SPRED2,FRS2A,FGFR1B |
| DAP12 interactions | GRAP2B,DUSP10,CLEC5A,GRAP2A,NEFLB,FGFR1B,SIRPB1,RASGRP1,FRS2A,KLB |
| Axon guidance | NRG4,CNTN6,AP2B1,TRPC3,LRRC4,LAMTOR2,EPHB4B,PAQR3B,ITSN1,DOCK1 |
| Downstream signal transduction | IL17RD,TRAT1,LAMTOR2,FGF10B,RASGEF1A,SPRED3,CRKL,SPNA1,PHB,PAQR3A |
| Developmental Biology | CNTN6,MYL12B,EVL,POU5F3,EGR2,CARM1,RGMA,NTN1B,AP2M1,CRMP1 |
| Cytokine Signaling in Immune system | IL1RN,PRLRB,TNFSF13B,GBP5,PTPRA,FRS2,RASGRP4,PEBP1,IRF2,EIF4E |
Protein Function
CNKSR1 has several biochemical functions, for example, protein binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CNKSR1 itself. We selected most functions CNKSR1 had, and list some proteins which have the same functions with CNKSR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding, bridging | DDX20,LOR,PPP2R3A,STX1A,WWC1,FLRT1,SLC9A1,PSMC6,FKBP4,CAV2 |
| protein binding | SGTB,STIP1,THAP11,CD5,CCDC22,PIK3IP1,LCORL,FASTKD5,OTUB1,TAG-260 |
Interacting Protein
CNKSR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNKSR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNKSR1.
CYTH3;PIN1;CYTH4;RHOA;RHOC;RHOH;Raf1;SMAD4;ZDHHC17
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References
- Soundararajan, R; Ziera, T; et al. Scaffold Protein Connector Enhancer of Kinase Suppressor of Ras Isoform 3 (CNK3) Coordinates Assembly of a Multiprotein Epithelial Sodium Channel (ENaC)-regulatory Complex. JOURNAL OF BIOLOGICAL CHEMISTRY 287:33014-33025(2012).
- Farhan, H; Wendeler, MW; et al. MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening. JOURNAL OF CELL BIOLOGY 189:997-1011(2010).
