CMBL
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Official Full Name
carboxymethylenebutenolidase homolog (Pseudomonas) -
Overview
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 -
Synonyms
CMBL;carboxymethylenebutenolidase homolog (Pseudomonas);carboxymethylenebutenolidase like (Pseudomonas);carboxymethylenebutenolidase homolog;FLJ23617;CMBL_HUMAN;carboxymethylenebutenolidase-like (Pseudomonas)
Recombinant Proteins
- Rat
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CMBL involved in several pathways and played different roles in them. We selected most pathways CMBL participated on our site, such as Biosynthesis of antibiotics,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CMBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biosynthesis of antibiotics | CS,ADSL,ACAA2,GLYCTK,LDHAL6B,pykF,AK8,AKR1A1,SDSL,GPR19 |
| Metabolic pathways | EBP,IDH3A,PLCD4,POLR3F,UPB1,POLR2B,CYP26B1,CYP2P6,DNMT4,POLA1 |
Protein Function
CMBL has several biochemical functions, for example, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CMBL itself. We selected most functions CMBL had, and list some proteins which have the same functions with CMBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | KLK1B9,DUSP8A,MBLAC2,CLCA3,PRSS44,THTPA,MCM3L,ADAM1B,NCEH1B,CHD1L |
Interacting Protein
CMBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CMBL here. Most of them are supplied by our site. Hope this information will be useful for your research of CMBL.
CD2BP2;ATIC;ARRB1;CUL2;EIF4A2;TRIP6;SMYD2;PUF60;2_aha_camp;8-aha-camp;8-aha-omethyladenosine;SAP30;Chmp6;H2AFX;SNCA;SMS;Crocc;KIF20B
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