CLTC
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Official Full Name
clathrin, heavy chain (Hc) -
Overview
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008] -
Synonyms
CLTC;clathrin, heavy chain (Hc);Hc;CHC;CHC17;CLH-17;CLTCL2;clathrin heavy chain 1;clathrin, heavy polypeptide (Hc);clathrin, heavy polypeptide-like 2;clathrin heavy chain on chromosome 17
Recombinant Proteins
- Rat
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- His&Fc&Avi
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLTC-1471R | Recombinant Rat CLTC Protein | Mammalian Cell | Rat | His |
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| CLTC-26707TH | Recombinant Human CLTC, GST-tagged | Wheat Germ | Human | GST |
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| CLTC-3605C | Recombinant Chicken CLTC | Mammalian Cell | Chicken | His |
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| CLTC-3612M | Recombinant Mouse CLTC Protein | Mammalian Cell | Mouse | His |
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| CLTC-1129R | Recombinant Rat CLTC Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CLTC-1129R-B | Recombinant Rat CLTC Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CLTC-1773M | Recombinant Mouse CLTC Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CLTC-1773M-B | Recombinant Mouse CLTC Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CLTC-802H | Recombinant Human CLTC Protein, His&GST-tagged | E.coli | Human | His&GST | Ala2-Pro242 |
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Involved Pathway
CLTC involved in several pathways and played different roles in them. We selected most pathways CLTC participated on our site, such as Adaptive Immune System,Arf6 trafficking events,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLTC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | ACTR3,EFNA1A,MYL12B,PITPNA,SLIT2,DPYSL4,DOCK1,JAK3,ITGB1B.1,TRPC7 |
| Adaptive Immune System | Siglece,CDKN1A,FGF18B,ASB14,TREML4,AP2M1,KIF15,SIGLEC9,RNF138,IGKC |
| Bacterial invasion of epithelial cells | CAV1,DOCK1,SHC2,CLTA,CTNNA3,RHOG,BCAR1,PIK3R5,SEPT6,HCLS1 |
| Arf6 trafficking events | DNM2,EXOC1,CTNND1,EDNRB,SCAMP2,JUP,EXOC5,PTBP3,ADRB2,SPAG9 |
| Beta-catenin independent WNT signaling | ROR1,DVL1,CTNNB2,ITPR2,AP2M1,DVL2,AP2A2,ROR2,AP2A1,PRICKLE1B |
| EPH-Ephrin signaling | EFNA4,MYL12B,EFNA1,DNM1,ACTR3,KDR,EPHA2,ARPC3,AP2S1,KALRNB |
| Developmental Biology | EZRA,LGI2A,AP2A2,MED15,PTPRA,CDH4,DUSP1,ARPC3,SREBF2,PAQR3A |
| Clathrin derived vesicle budding | AP1B1,PICALMA,CNO,CLINT1,DNM2,YIPF6,FTH1B,CTSZ,DTNBP1,SH3D19 |
Protein Function
CLTC has several biochemical functions, for example, clathrin light chain binding,double-stranded RNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLTC itself. We selected most functions CLTC had, and list some proteins which have the same functions with CLTC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| clathrin light chain binding | CALY,NSG2,HMP19,NSG1 |
| double-stranded RNA binding | OAS1,DDX21,TUBB4B,VIM,HSPD1,RFTN1,ELAVL1,TUBA1B,DHX30,DHX15 |
| poly(A) RNA binding | REPIN1,POLDIP3,EIF3G,SAP18,MRPS9,PDIA3,OASL1,DDX31,SNRPA,HDAC2 |
| protein kinase binding | AXIN1,GRIN2A,DUSP3,EPHA1,PTPN2,GSK3B,PPP1R12B,NBEA,XBP1,BCL2L14 |
| structural molecule activity | CKI,LAMA5,NES,CRCT1,COL4A3,SPRR2H,FGB,SNTG1,LMNA,CLDNK |
| protein binding | CRY1A,PPP5C,NPM3,NAA16,BCL2A1,SNX32,THOP1,PREP,FZD2,AGXT2L2 |
Interacting Protein
CLTC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLTC here. Most of them are supplied by our site. Hope this information will be useful for your research of CLTC.
OCRL;TNK2;IKBKB;IKBKE;HIP1;C10orf88;TOM1L1
CLTC Related Signal Pathway
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