CLDN22
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Official Full Name
claudin 22 -
Overview
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3 UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. -
Synonyms
CLDN22;claudin 22;claudin-22;CLDN21;CLD22_HUMAN;FLJ51450
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- Mammalian cells
- E.coli expression system
- His
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
CLDN22 involved in several pathways and played different roles in them. We selected most pathways CLDN22 participated on our site, such as Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | IKBKG,IFNA7,NFKB1,KRAS,CLDN23,PIK3R5,TNFRSF1A,Ifna15,CLDN10,IRF3 |
| Cell adhesion molecules (CAMs) | ITGB2L,OCLN,CNTN1,NRXN2A,ITGB1B.2,Itgam&Itgb2,BLB2,PVRL2,CD80,BF2 |
| Leukocyte transendothelial migration | Itgam&Itgb2,PRKCA,VAV2,ACTN2,RHOA,VAV1,ITGB2L,JAM2,CLDN5,CYBA |
| Tight junction | MYL10,CLDNA,MYH9A,ACTN2B,RAB13,ACTN3A,ACTB,PARD6A,NRAS,AKT1 |
Protein Function
CLDN22 has several biochemical functions, for example, molecular_function,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN22 itself. We selected most functions CLDN22 had, and list some proteins which have the same functions with CLDN22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | MPEG1.1,PNPLA4,XKR9,FAM179A,SMR3B,CCDC85CA,GRCC10,DCHS1,TMEM144,COMMD4 |
| structural molecule activity | KRT1-C5,CLDNK,EPB41L3A,MPZL1,KRT83,CLTC,KRT71,MPZ,ODF2,SPRR1B |
Interacting Protein
CLDN22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN22.
Resources
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References
- Tominaga, A; Konishi, Y; et al. Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides. INTERNATIONAL IMMUNOPHARMACOLOGY 17:1009-1019(2013).
- Bauerschlag, D; Brautigam, K; et al. Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 139:347-355(2013).
