CLDN14
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Official Full Name
claudin 14 -
Overview
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. -
Synonyms
CLDN14;claudin 14;DFNB29;claudin-14;MGC109472;AI851731;CLD14_HUMAN;CLDN 14;DFNB 29;Human CLDN14 gene;OTTHUMP00000109046;OTTHUMP00000109049;OTTMUSP00000021531;UNQ777/PRO1571
Recombinant Proteins
- Human
- Rhesus macaque
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLDN14-1430H | Recombinant Human CLDN14 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLDN14-893R | Recombinant Rhesus monkey CLDN14 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CLDN14-7470HCL | Recombinant Human CLDN14 293 Cell Lysate | HEK293 | Human | Non |
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| CLDN14-2041HF | Recombinant Full Length Human CLDN14 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 239 amino acids |
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| CLDN14-719R | Recombinant Rhesus Macaque CLDN14 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CLDN14-719R-B | Recombinant Rhesus Macaque CLDN14 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RFL21545HF | Recombinant Full Length Human Claudin-14(Cldn14) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-239) |
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Involved Pathway
CLDN14 involved in several pathways and played different roles in them. We selected most pathways CLDN14 participated on our site, such as Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | MAVS,TRP53,IFNAR1,STAT2,MAPK9,PIK3R5,EIF2AK1,EIF2AK2,CLDN3,CLDN18 |
| Tight junction | MYL2B,CLDN11A,PPP2R1A,GNAI2B,CSDA,PARD6B,CTNNA3,MYH1E,GNAI2,VAPA |
| Cell adhesion molecules (CAMs) | CNTNAP1,CLDN2,MPZL1L,NRXN1A,ALCAMA,SELPLG,CLDN15LB,VTCN1,PECAM1,LRRC4 |
| Leukocyte transendothelial migration | CLDN20,NCF4,ITGAM,CLDN6,PXN,RAC2,CLDN18,ITGB2,Itgam&Itgb2,VCAM1 |
Protein Function
CLDN14 has several biochemical functions, for example, identical protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN14 itself. We selected most functions CLDN14 had, and list some proteins which have the same functions with CLDN14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | CLDN4,MUL1,SH3BP4,SDF4,LRRK2,CLDN16,LCK,C1QL4,PARK7,MICU1 |
| structural molecule activity | KRT24,SPRR2G,LAMB2,KRTAP3-1,KRT28,NUMA1,KRT18,LCE3D,SEMG1,CLDNF |
Interacting Protein
CLDN14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN14.
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References
- Agaimy, A; Buslei, R; et al. Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel. HISTOPATHOLOGY 65:60-70(2014).
- Jo, VY; Cibas, ES; et al. Claudin-4 immunohistochemistry is highly effective in distinguishing adenocarcinoma from malignant mesothelioma in effusion cytology. CANCER CYTOPATHOLOGY 122:299-306(2014).
