CLCNKA
-
Official Full Name
chloride channel Ka -
Overview
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CLCNKA;chloride channel Ka;chloride channel protein ClC-Ka;hClC Ka;MGC61490;C75963;Chloride channel kidney A;Chloride channel protein ClC Ka;ClC K1;CLCK1;MGC93313;RP23-308N2.5;chloride channel, kidney, A;ClC-K1;hClC-Ka
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLCNKA-11281H | Recombinant Human CLCNKA, GST-tagged | E.coli | Human | GST | 515-687a.a. | |
| CLCNKA-3353H | Recombinant Human CLCNKA protein, His-tagged | E.coli | Human | His | 515-687 aa | |
| CLCNKA-1429R | Recombinant Rat CLCNKA Protein | Mammalian Cell | Rat | His |
|
|
| CLCNKA-3519M | Recombinant Mouse CLCNKA Protein | Mammalian Cell | Mouse | His |
|
|
| CLCNKA-1087R | Recombinant Rat CLCNKA Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| CLCNKA-1087R-B | Recombinant Rat CLCNKA Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| CLCNKA-1723M | Recombinant Mouse CLCNKA Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| CLCNKA-1723M-B | Recombinant Mouse CLCNKA Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
CLCNKA involved in several pathways and played different roles in them. We selected most pathways CLCNKA participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCNKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stimuli-sensing channels | CLCN1,ANO1,TRPC5,Ano3,ASIC1A,ANO5,TRPV3,CLCA1,BEST3,TTYH3 |
| Ion channel transport | ANO6,TCIRG1,NHEDC1,TTYH3,WNK2,ATP1A1A.5,ATP13A5,CLCN7,ANO7,TRPM4C |
| Transmembrane transport of small molecules | ADD3,TTYH3B,LCN15,OSTM1,SLC35A3,SLC20A1,ANKHB,SLC1A3B,WNK1,ATP2B3A |
Protein Function
CLCNKA has several biochemical functions, for example, metal ion binding,voltage-gated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCNKA itself. We selected most functions CLCNKA had, and list some proteins which have the same functions with CLCNKA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated chloride channel activity | CLCN2,CLCN4-2,CLCN1,CLCN5,CLCN4,CLCN7,CLCN6,CLCN3,CLCNKB,ANO6 |
| metal ion binding | SP3,KIN,ZNF556,STAC,CLCA1,PFKMB,PPM1BB,ZC3H15,ZNF367,ZBTB9 |
Interacting Protein
CLCNKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCNKA here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCNKA.
Resources
Related Services
Related Products
References
