CLCN6
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Official Full Name
chloride channel 6 -
Overview
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB. -
Synonyms
CLCN6;chloride channel 6;chloride transport protein 6;ClC 6;KIAA0046;ClC6;OTTHUMP00000002410;OTTHUMP00000002411;OTTHUMP00000002412;OTTHUMP00000002413;OTTHUMP00000002414;chloride channel protein 6;CLC-6
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLCN6-1420H | Recombinant Human CLCN6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLCN6-3517M | Recombinant Mouse CLCN6 Protein | Mammalian Cell | Mouse | His |
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| CLCN6-5472C | Recombinant Chicken CLCN6 | Mammalian Cell | Chicken | His |
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| CLCN6-889R | Recombinant Rhesus monkey CLCN6 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CLCN6-1721M | Recombinant Mouse CLCN6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CLCN6-1721M-B | Recombinant Mouse CLCN6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CLCN6-1996HF | Recombinant Full Length Human CLCN6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 869 amino acids |
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| CLCN6-715R | Recombinant Rhesus Macaque CLCN6 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CLCN6-715R-B | Recombinant Rhesus Macaque CLCN6 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CLCN6 involved in several pathways and played different roles in them. We selected most pathways CLCN6 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ion channel transport | CLIC2,ATP13A1,WNK1,BEST3,ASPH,CLCN7,TRPA1B,ATP1A1A.5,FXYD7,ATP10A |
| Transmembrane transport of small molecules | MATE4,SLC43A2,MIPA,SLCO4C1,SLC2A13,SLC15A4,CLCNKA,SLC30A8,WNK2,SLC47A1 |
| Stimuli-sensing channels | ANO8,TRPC4APB,SLC9B2,BEST4,TTYH3,TRPC4APA,NHEDC1,ANO5,TRPC4A,TSC22D3 |
Protein Function
CLCN6 has several biochemical functions, for example, ATP binding,antiporter activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN6 itself. We selected most functions CLCN6 had, and list some proteins which have the same functions with CLCN6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| antiporter activity | SLC7A8,SLC35E4,SLC47A1,SLC35E1,SLC9A3.1,SLC35C2,SLC47A2,TMCO3,Slc4a2,SLC9A9 |
| nucleotide binding | RBM14B,SRSF4,RHOAC,TINAG,MYO5A,ARL8BA,STK24A,HNRNPA0B,AKAP7,ZRSR2 |
| ion channel activity | CATSPER2,GJC1,KCNG4A,TRPC2,GRIK3,NALCN,TRPV5,CHRNB3B,TRPM5,SCN4AA |
| voltage-gated chloride channel activity | CLCN7,CLCNK,CLCNKA,CLCN4,CLCNKB,CLCN2,ANO6,CLCN4-2,CLCN1A,CLCN5 |
| ATP binding | OLA1,ATAD5,UCKL1A,CSNK1G2B,NAIP1,CAMK1D,HSPA5,MAP4K2,CLK1,PIP5K2 |
Interacting Protein
CLCN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN6.
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References
- Ohshiro, J; Yamamura, H; et al. The multiple expression of Ca2+-activated Cl- channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 443:518-523(2014).
- Wahl, V; Vogler, S; et al. OSTEOPONTIN INHIBITS OSMOTIC SWELLING OF RETINAL GLIAL (MULLER) CELLS BY INDUCING RELEASE OF VEGF. NEUROSCIENCE 246:59-72(2013).
