CLCN5

  • Official Full Name

    chloride channel 5

  • Overview

    This gene encodes a member of the ClC family of chloride ion channels and ion transporters. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    CLCN5;chloride channel 5;nephrolithiasis 1 (X linked) , nephrolithiasis 2, X linked , NPHL1, NPHL2;H(+)/Cl(-) exchange transporter 5;ClC 5;CLC5;Dent disease;DENTS;hCIC K2;hClC K2;XLRH;XRN;Chloride channel protein 5;Chloride transporter ClC-5;ClC-5;CLCK2;CLCN5_HUMAN;hCIC-K2;NPHL1;NPHL2;OTTHUMP00000023279;OTTHUMP00000023280;OTTHUMP00000023281;OTTHUMP00000023282;hClC-K2

Recombinant Proteins

  • Human
  • Rat
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLCN5-3998H Recombinant Human CLCN5 protein, His-tagged E.coli Human His 627-685 aa
CLCN5-1418H Recombinant Human CLCN5 Protein, GST-tagged Wheat Germ Human GST
CLCN5-1427R Recombinant Rat CLCN5 Protein Mammalian Cell Rat His
CLCN5-7473HCL Recombinant Human CLCN5 293 Cell Lysate HEK293 Human Non
CLCN5-1085R Recombinant Rat CLCN5 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CLCN5-1085R-B Recombinant Rat CLCN5 Protein Pre-coupled Magnetic Beads HEK293 Rat
CLCN5-1995HF Recombinant Full Length Human CLCN5 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 746 amino acids

    Involved Pathway

    CLCN5 involved in several pathways and played different roles in them. We selected most pathways CLCN5 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transmembrane transport of small molecules SLC9A10,TTYH3,SLC2A7,TPCN1,SLC5A3A,SLC17A3,MIPB,MCOLN2,SLC39A10,SLC4A1A
    Ion channel transport GSDMA2,TTYH1,CUTC,FXYD7,ATP2B1B,ANO5,TRPC4APA,BSND,TRPC5A,FXYD6
    Stimuli-sensing channels CLCN2,TRPC4APB,WNK2,MCOLN3,TRPC4APA,TTYH3,MCOLN2,TRPM1A,ASIC1A,ANO8

    Protein Function

    CLCN5 has several biochemical functions, for example, ATP binding,antiporter activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN5 itself. We selected most functions CLCN5 had, and list some proteins which have the same functions with CLCN5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TMEM38A,WNK1,EIF4A1A,IP6K3,DHX8,GRK6,UBE2D1,MTOR,FYNA,DCK
    chloride channel activity TTYH2,GABRA4,GABRP,SLC26A4,TTYH3,GABRB2,FXYD1,TTYH2L,CLCA4,CLIC3
    voltage-gated chloride channel activity CLCN2,CLCN1A,CLCN4,CLCN1,CLCN4-2,CLCN7,CLCN3,CLCNKA,CLCNK,CLCNKB
    antiporter activity SLC7A8,SLC25A16,SLC9A4,SLC7A10,SLC26A3.2,Slc4a2,SLC7A4,SLC26A1,SLC35E4,TMEM241

    Interacting Protein

    CLCN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN5.

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