CLCN4
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Official Full Name
chloride channel, voltage-sensitive 4 -
Overview
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. -
Synonyms
CLCN4;chloride channel, voltage-sensitive 4;chloride channel 4;H(+)/Cl(-) exchange transporter 4;ClC 4;CLC4;chloride channel protein 4;chloride transporter ClC-4;ClC-4;ClC-4A;MGC163150;Clc4-2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLCN4-2-3515M | Recombinant Mouse CLCN4-2 Protein | Mammalian Cell | Mouse | His |
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| CLCN4-4679Z | Recombinant Zebrafish CLCN4 | Mammalian Cell | Zebrafish | His |
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| CLCN4-7474HCL | Recombinant Human CLCN4 293 Cell Lysate | HEK293 | Human | Non |
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| CLCN4-1720M | Recombinant Mouse CLCN4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CLCN4-1720M-B | Recombinant Mouse CLCN4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
CLCN4 involved in several pathways and played different roles in them. We selected most pathways CLCN4 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | SLC28A3,AQP9B,FTH1B,SLCO2B1,APOD,AQP8A.1,ASIC1A,GSDMA2,RHAG,SLC7A8A |
| Ion channel transport | FXYD7,MCOLN2,ANO5,CLCN6,TTYH1,Ano3,TPCN1,ATP1A1A.3,TRPC4,TRPC4A |
| Stimuli-sensing channels | TRPA1A,ANO6,SRI,TTYH2,MCOLN3,TRPC4,UNC79,ANO9,TRPM1,ASPH |
Protein Function
CLCN4 has several biochemical functions, for example, ATP binding,antiporter activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN4 itself. We selected most functions CLCN4 had, and list some proteins which have the same functions with CLCN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP10A,ACSBG1,ULK1A,CAMK2G,RPS6KA1,PARS2,ATP11A,FIGNL2,PAPOLB,UBE2B |
| voltage-gated chloride channel activity | CLCN6,CLCN3,ANO6,CLCNKB,CLCNK,CLCN7,CLCN1,CLCN2,CLCN4-2,CLCNKA |
| antiporter activity | SLC4A8,SLC7A7,SLC26A3.2,CLCN5,SLC8A1,SLC25A16,SLC7A3,SLC9A6B,SLC7A14,SLC7A3A |
| chloride channel activity | GABRA3,CLCN7,SLC26A4,GABRE,CLIC4,CLIC3,SLC26A6,CLIC5B,CLCA4,CLCA2 |
Interacting Protein
CLCN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN4.
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References
- Johanneson, B; Chen, D; et al. Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study. CARCINOGENESIS 35:2084-2088(2014).
- Wright, GWJ; Parsons, SP; et al. Cholinergic signalling-regulated K(V)7.5 currents are expressed in colonic ICC-IM but not ICC-MP. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 466:1805-1818(2014).
