CIT
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Official Full Name
citron (rho-interacting, serine/threonine kinase 21) -
Overview
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. -
Synonyms
CIT;citron (rho-interacting, serine/threonine kinase 21);citron Rho-interacting kinase;CRIK;KIAA0949;STK21;serine/threonine-protein kinase 21
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CIT-827H |
Active Recombinant Human CIT, GST-tagged
|
Sf9 Cells | Human | GST | 1-449 |
|
| CIT-1383H | Active Recombinant Human CIT Protein, GST-tagged | Insect Cells | Human | GST | 1-449 a.a. |
|
| CIT-1384H | Recombinant Human CIT Protein, GST-tagged | Wheat Germ | Human | GST |
|
Involved Pathway
CIT involved in several pathways and played different roles in them. We selected most pathways CIT participated on our site, such as G13 Signaling Pathway,RHO GTPase Effectors,RHO GTPases activate CIT, which may be useful for your reference. Also, other proteins which involved in the same pathway with CIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RHO GTPase Effectors | FMNL1,IQGAP3,WASF3,SKA1,ABI2,CDCA8,NUF2,PRC1B,TAX1BP3,ABI1 |
| RHO GTPases activate CIT | PRC1,PRC1B,KIF14,RHOAE |
| Signal Transduction | PTH,PTGDR2,ARHGAP12B,CDH5,ARHGAP28,RGS21,RDH14B,SOX4A,EFCAB7,SOUL4 |
| Signaling by Rho GTPases | ARHGAP6,ARHGAP23,RHOJ,GMIP,ABI1A,ARHGEF16,FGD4A,ARHGEF18A,ARHGAP29,MYO9B |
| G13 Signaling Pathway | ARHGEF1A,GNA13,SH3RF1,RTKN,RHPN2,DIAPH1,MYL1,TNK2,MYBPH,CFL2 |
Protein Function
CIT has several biochemical functions, for example, ATP binding,PDZ domain binding,SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CIT itself. We selected most functions CIT had, and list some proteins which have the same functions with CIT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | SH3BP5B,SOS1,SH3BP5,SGIP1,EVL,DPYSL3,ITGB1BP2,ADAM12,ILK,RAD9 |
| protein serine/threonine kinase activity | MAP4K3,ULK2,PKZ,RPS6KA2,NUAK2,EIF2AK2,ACVR1L,PKN1B,UHMK1,RIPK1 |
| protein binding | SNX11,PPP2R2A,RFX4,STOX1,GTF3C3,NR4A1,KRTAP10-7,KIF9,CDC42EP1,ZNF747 |
| ATP binding | KIF2A,CCT8L2,HSPA7,UBE2E1,FGFR1,NEK1,TPX2,CAMK1GA,MSH4,BMX |
| metal ion binding | ZNF446,BCL11BA,SMPD3,ADIPOR2,GALNTL1,KEL,CSGALNACT1,HIC1L,KLF15,Reln |
| scaffold protein binding | SCN5A,KRT8,NOS3,VIM,MAPK3,MAP2K2,HOMER1,NLGN4X,TREM1,CACNA1G |
| PDZ domain binding | LNX1,ARHGEF16,KIDINS220B,PROSAPIP1,DOCK4,CLCN3,ATP2B3B,GRIK5,ATP2B3A,DLG3 |
Interacting Protein
CIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CIT here. Most of them are supplied by our site. Hope this information will be useful for your research of CIT.
MYL12A
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References
- Xu, Y; Xiong, L; et al. Citrinin detection using phage-displayed anti-idiotypic single-domain antibody for antigen mimicry. FOOD CHEMISTRY 177:97-101(2015).
- Uchiyama, MK; Deda, DK; et al. In vivo and In vitro Toxicity and Anti-Inflammatory Properties of Gold Nanoparticle Bioconjugates to the Vascular System. TOXICOLOGICAL SCIENCES 142:497-507(2014).
