CISH
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Official Full Name
cytokine inducible SH2-containing protein -
Overview
The suppressor of cytokine signaling (SOCS) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway (1-3). The SOCS family consists of at least 8 members including the originally identified cytokine-inducib -
Synonyms
CISH;cytokine inducible SH2-containing protein;cytokine-inducible SH2-containing protein;CIS;CIS 1;G18;SOCS;suppressor of cytokine signaling;cytokine-inducible inhibitor of signaling type 1B;CIS-1;BACTS2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
CISH involved in several pathways and played different roles in them. We selected most pathways CISH participated on our site, such as Cytokine Signaling in Immune system,EPO Receptor Signaling,Growth hormone receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CISH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | STAT5B,IFNAR1,IL13,IFNK,GRB2B,BCL2A,IFNAR2,IRX1,GH1,PIK3R3A |
| EPO Receptor Signaling | PTPRUB,PTPRU |
| Cytokine Signaling in Immune system | EIF4E3,DPF1,BST2,PRLRB,CASPBL,IFI6,FGF10B,DUSP7,TRIM10,EDA |
| Growth hormone receptor signaling | CSH1,CSHL1,PRLRB,GHRB |
| IL2-mediated signaling events | DOK2,IKZF3,STAM2 |
| Immune System | ALCAMB,CTSE,CLEC2H,ASB4,ART1,KLRB1A,RNF19B,OSCAR,DEFA5,S100A12 |
| IL-2 Signaling Pathway | SHB,NMI,ITM2BA,CD53 |
| IL-3 Signaling Pathway | KCNIP3B,GATA2A,GATA1A,GATA2,BIRC5A,GNB2L1,GSK3AB,PILRB,SPI1B,BMX |
Protein Function
CISH has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CISH itself. We selected most functions CISH had, and list some proteins which have the same functions with CISH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | VWA5B1,TMEM179,FAM53B,TPM4B,VMN1R95,SLC25A48,ASPSCR1,ZNF75A,GSDMC,DDX19A |
| protein binding | INADL,CD40,CCNA2,MAGEB18,SLC2A4,LRRFIP1,IFITM3,TRIM5,MAPK9,NOSIP |
Interacting Protein
CISH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CISH here. Most of them are supplied by our site. Hope this information will be useful for your research of CISH.
EGFR;ERBB2;HSPA6;EPOR;ETV5;MAP3K7CL;SMAD2;Epor;DYNLL1
Resources
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References
- Esteves, LM; Bulhoes, SM; et al. Human Leptospirosis: Seroreactivity and Genetic Susceptibility in the Population of Sao Miguel Island (Azores, Portugal). PLOS ONE 9:-(2014).
- Yan, B; Kuick, CH; et al. Platform Comparison for Evaluation of ALK Protein Immunohistochemical Expression, Genomic Copy Number and Hotspot Mutation Status in Neuroblastomas. PLOS ONE 9:-(2014).
