CIRH1A
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Official Full Name
cirrhosis, autosomal recessive 1A (cirhin) -
Overview
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. -
Synonyms
CIRH1A;cirrhosis, autosomal recessive 1A (cirhin);cirhin;FLJ14728;KIAA1988;NAIC;TEX292;UTP4;small subunit (SSU) processome component;homolog (yeast);FLJ17146;testis expressed gene 292;UTP4, small subunit (SSU) processome component, homolog
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CIRH1A-11253H | Recombinant Human CIRH1A, GST-tagged | E.coli | Human | GST | C-term-350a.a. | |
| CIRH1A-12475Z | Recombinant Zebrafish CIRH1A | Mammalian Cell | Zebrafish | His |
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| CIRH1A-1376H | Recombinant Human CIRH1A Protein, GST-tagged | Wheat Germ | Human | GST |
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| CIRH1A-3480M | Recombinant Mouse CIRH1A Protein | Mammalian Cell | Mouse | His |
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| CIRH1A-1696M | Recombinant Mouse CIRH1A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CIRH1A-1696M-B | Recombinant Mouse CIRH1A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CIRH1A-1854HF | Recombinant Full Length Human CIRH1A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 686 amino acids |
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Involved Pathway
CIRH1A involved in several pathways and played different roles in them. We selected most pathways CIRH1A participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CIRH1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | NHP2L1,IMP3,GTPBP4,NHP2L1B,ACK2,TCOF1,cka2,RIOK1,PWP2,DROSHA |
Protein Function
CIRH1A has several biochemical functions, for example, poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CIRH1A itself. We selected most functions CIRH1A had, and list some proteins which have the same functions with CIRH1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | DHX33,ANKHD1,ELAC2,LRRC47,RPL26L1,SRP14,ZCCHC8,CSTF2,DDX55,SRSF4 |
| protein binding | HHLA2,SNX17,ARL6IP1,HS3ST5,LDHA,MPDU1,SSX2,AGTR1A,RPRD1A,MYRIP |
Interacting Protein
CIRH1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CIRH1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CIRH1A.
HIVEP1;PRNP;uxaA;pgl;NOP56;VPS26A;AK1;FOS;KIF22;IFI16;CERK;HDAC11;Nrip3;HDAC6
Resources
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References
- Wada, K; Sato, M; et al. Dynamics of WD-repeat containing proteins in SSU processome components. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 92:191-199(2014).
- Sato, M; Araki, N; et al. Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub-complex. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 91:466-475(2013).
