CHST6
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Official Full Name
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 -
Overview
The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). -
Synonyms
CHST6;carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6;MCDC1;carbohydrate sulfotransferase 6;C GlcNAc6ST;Carbohydate sulfotransferase 6;Carbohydrate (N acetylglucosamine 6 O) sulfotransferase 6;Corneal N acetylglucosamine 6 sulfotransferase;Galactose N acetylglucosamine N acetylglucosamine 6 O sulfotransferase 4 beta;GlcNAc6ST 5;GST4 beta;hCGn6ST;Macular dystrophy corneal 1;gn6st-5;GST4-beta;C-GlcNAc6ST;glcNAc6ST-5;N-acetylglucosamine 6-O-sulfotransferase 5;corneal N-acetylglucosamine 6-sulfotransferase;corneal N-acetylglucosamine-6-O-sulfotransferase;galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHST6-2716H | Recombinant Human CHST6 protein, His-tagged | E.coli | Human | His | 211-287 aa | |
| CHST6-738H |
Active Recombinant Human CHST6 Protein, His-tagged
|
CHO | Human | His | Ser27-Asn395 |
|
| CHST6-1347H | Recombinant Human CHST6 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| CHST6-327H | Recombinant Human CHST6 Protein, His-tagged | E.coli | Human | His |
|
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| CHST6-5464C | Recombinant Chicken CHST6 | Mammalian Cells | Chicken | His |
|
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| CHST6-7506HCL | Recombinant Human CHST6 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
CHST6 involved in several pathways and played different roles in them. We selected most pathways CHST6 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - keratan sulfate | CHST2A,ST3GAL2,CHST1,ST3GAL3,B3GNT7,B4GALT1,ST3GAL3B,Chst5,B4GALT4,B3GNT2B |
Protein Function
CHST6 has several biochemical functions, for example, N-acetylglucosamine 6-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST6 itself. We selected most functions CHST6 had, and list some proteins which have the same functions with CHST6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetylglucosamine 6-O-sulfotransferase activity | SULT1ST6,SULT1ST8,Sult3a1,SULT2ST3,GAL3ST3,SULT2ST2,SULT1ST4,SULT1ST7,SULT6B1,CHST2A |
Interacting Protein
CHST6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST6.
Resources
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References
- Nakayama, F; Umeda, S; et al. Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines. FEBS LETTERS 587:231-237(2013).
- Di Iorio, E; Barbaro, V; et al. Localization and expression of CHST6 and keratan sulfate proteoglycans in the human cornea. EXPERIMENTAL EYE RESEARCH 91:293-299(2010).
