CHRNG
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Official Full Name
cholinergic receptor, nicotinic, gamma -
Overview
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis. -
Synonyms
CHRNG;cholinergic receptor, nicotinic, gamma;ACHRG, cholinergic receptor, nicotinic, gamma polypeptide;acetylcholine receptor subunit gamma;Acetylcholine receptor muscle gamma subunit;Acetylcholine receptor protein gamma chain precursor;ACHG;Achr 3;Achr3;ACHRG;ACRG;Cholinergic receptor nicotinic gamma;Cholinergic receptor nicotinic gamma polypeptide;MGC133376;OTTHUMP00000203703;OTTHUMP00000203704;acetylcholine receptor, muscle, gamma subunit;cholinergic receptor, nicotinic, gamma polypeptide
Recombinant Proteins
- Rat
- Mouse
- Chicken
- Zebrafish
- Human
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- E.coli
- Yeast
- His
- His&Fc&Avi
- His&GST
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
CHRNG-1402R | Recombinant Rat CHRNG Protein | Mammalian Cell | Rat | His | ||
Chrng-3058M | Recombinant Mouse Chrng, His-tagged | E.Coli or Yeast | Mouse | His | 519 | |
CHRNG-3210C | Recombinant Chicken CHRNG | Mammalian Cell | Chicken | His | ||
CHRNG-8109Z | Recombinant Zebrafish CHRNG | Mammalian Cell | Zebrafish | His | ||
CHRNG-1060R | Recombinant Rat CHRNG Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi | ||
CHRNG-1060R-B | Recombinant Rat CHRNG Protein Pre-coupled Magnetic Beads | HEK293 | Rat | |||
CHRNG-1730H | Recombinant Human CHRNG Protein (Arg23-Ala250), N-His tagged | E.coli | Human | His | Arg23-Ala250 | |
CHRNG-1839H | Recombinant Human CHRNG Protein, His-tagged | Yeast | Human | His | ||
CHRNG-5645H | Recombinant Human CHRNG protein, His-tagged | E.coli | Human | His | 23-240aa | |
CHRNG-783H | Recombinant Human CHRNG Protein, His&GST-tagged | E.coli | Human | His&GST | Arg23-Ala250 |
Involved Pathway
CHRNG involved in several pathways and played different roles in them. We selected most pathways CHRNG participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Neuroactive ligand-receptor interaction | HCRTR2,HTR1AB,ADORA1,LEP,AGTR2,PPYR1,NTSR1,AVPR1B,GABRG3,GABBR2 |
Protein Function
CHRNG has several biochemical functions, for example, acetylcholine-activated cation-selective channel activity,extracellular ligand-gated ion channel activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNG itself. We selected most functions CHRNG had, and list some proteins which have the same functions with CHRNG. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
extracellular ligand-gated ion channel activity | CHRNB1L,GABRR1,CHRNB3A,GLRBA,CHRNA4B,GLRBB,GABRP,CHRNB3,GABRR3,GABRR2A |
ligand-gated ion channel activity | CHRNB2,CHRNA3,ZACN,TRPA1A,CLCA2,P2RX2,CHRNB4,CLCA5,CHRNA4,CHRNB1 |
ion channel activity | TRPM5,HTR3B,CHRNB3B,KCNV2,TRPM1A,KCNK3,P2RX4A,SCN8AA,TRPC2B,TRPC5A |
protein binding | KCTD15,CATSPERB,RUSC1-AS1,KIFC3,RPL12,EIF3H,SEPT4,TM4SF4,UBE3C,CIC |
acetylcholine-activated cation-selective channel activity | CHRNB1L,CHRNB3B,CHRNA1,CHRNA4B,CHRND,CHRNB3A,CHRNA2,CHRNB3,CHRNB2,CHRNA6 |
Interacting Protein
CHRNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNG here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNG.
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