CHRNG

  • Official Full Name

    cholinergic receptor, nicotinic, gamma
  • Overview

    The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
  • Synonyms

    CHRNG;cholinergic receptor, nicotinic, gamma;ACHRG, cholinergic receptor, nicotinic, gamma polypeptide;acetylcholine receptor subunit gamma;Acetylcholine receptor muscle gamma subunit;Acetylcholine receptor protein gamma chain precursor;ACHG;Achr 3;Achr3;ACHRG;ACRG;Cholinergic receptor nicotinic gamma;Cholinergic receptor nicotinic gamma polypeptide;MGC133376;OTTHUMP00000203703;OTTHUMP00000203704;acetylcholine receptor, muscle, gamma subunit;cholinergic receptor, nicotinic, gamma polypeptide

Recombinant Proteins

  • Rat
  • Mouse
  • Chicken
  • Zebrafish
  • Human
  • Mammalian Cell
  • E.Coli or Yeast
  • HEK293
  • E.coli
  • Yeast
  • His
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
CHRNG-1402R Recombinant Rat CHRNG Protein Mammalian Cell Rat His
Chrng-3058M Recombinant Mouse Chrng, His-tagged E.Coli or Yeast Mouse His 519
CHRNG-3210C Recombinant Chicken CHRNG Mammalian Cell Chicken His
CHRNG-8109Z Recombinant Zebrafish CHRNG Mammalian Cell Zebrafish His
CHRNG-1060R Recombinant Rat CHRNG Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CHRNG-1060R-B Recombinant Rat CHRNG Protein Pre-coupled Magnetic Beads HEK293 Rat
CHRNG-1730H Recombinant Human CHRNG Protein (Arg23-Ala250), N-His tagged E.coli Human His Arg23-Ala250
CHRNG-1839H Recombinant Human CHRNG Protein, His-tagged Yeast Human His
CHRNG-5645H Recombinant Human CHRNG protein, His-tagged E.coli Human His 23-240aa
CHRNG-783H Recombinant Human CHRNG Protein, His&GST-tagged E.coli Human His&GST Arg23-Ala250

    Involved Pathway

    CHRNG involved in several pathways and played different roles in them. We selected most pathways CHRNG participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction HCRTR2,HTR1AB,ADORA1,LEP,AGTR2,PPYR1,NTSR1,AVPR1B,GABRG3,GABBR2

    Protein Function

    CHRNG has several biochemical functions, for example, acetylcholine-activated cation-selective channel activity,extracellular ligand-gated ion channel activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNG itself. We selected most functions CHRNG had, and list some proteins which have the same functions with CHRNG. You can find most of the proteins on our site.

    Function Related Protein
    extracellular ligand-gated ion channel activity CHRNB1L,GABRR1,CHRNB3A,GLRBA,CHRNA4B,GLRBB,GABRP,CHRNB3,GABRR3,GABRR2A
    ligand-gated ion channel activity CHRNB2,CHRNA3,ZACN,TRPA1A,CLCA2,P2RX2,CHRNB4,CLCA5,CHRNA4,CHRNB1
    ion channel activity TRPM5,HTR3B,CHRNB3B,KCNV2,TRPM1A,KCNK3,P2RX4A,SCN8AA,TRPC2B,TRPC5A
    protein binding KCTD15,CATSPERB,RUSC1-AS1,KIFC3,RPL12,EIF3H,SEPT4,TM4SF4,UBE3C,CIC
    acetylcholine-activated cation-selective channel activity CHRNB1L,CHRNB3B,CHRNA1,CHRNA4B,CHRND,CHRNB3A,CHRNA2,CHRNB3,CHRNB2,CHRNA6

    Interacting Protein

    CHRNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNG here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNG.

    Resources

    References

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