CHRM1
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Official Full Name
cholinergic receptor, muscarinic 1 -
Overview
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. -
Synonyms
Cholinergic receptor muscarinic 1;CHRM1;HM1;M1;Muscarinic acetylcholine receptor M1;cholinergic receptor, muscarinic 1;OTTHUMP00000236792;M1R;MGC30125;Muscarinic M1 Receptor
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- Pongo Abelii
- Macaca mulatta
- Sus scrofa (Pig)
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Yeast
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
- His&Flag
Involved Pathway
CHRM1 involved in several pathways and played different roles in them. We selected most pathways CHRM1 participated on our site, such as Amine ligand-binding receptors,Calcium Regulation in the Cardiac Cell,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR ligand binding | NMUR1,ADM2,PNOCB,CALCB,CCL35.2,ZFPM2B,LPAR2B,CCR3,ADORA1,GPR132 |
| Class A/1 (Rhodopsin-like receptors) | GPR77,GPR31B,ADRA2B,ANXA1,NMS,ADRB3,OPN5,CCL35.2,GPR37B,PNOCB |
| GPCR downstream signaling | CALCA,GPR65,ADRA2C,EDN1,RXFP2,DGKG,RXFP2B,ADRB3,ARHGEF17,CCR1 |
| Amine ligand-binding receptors | HRH3,ADRA1B,ADRB1,CHRM5,CHRM3,ADRA1D,DRD4,ADRA2A,ADRA2B,ADRB2 |
| Calcium signaling pathway | ERBB3B,PTK2B,OXTR,EDNRB2,CACNA1H,PDGFRB,GNAS,MYLK4,ADRB3A,MYLK3 |
| Calcium Regulation in the Cardiac Cell | KCNB1,GJC2,CHRM4,CASQ1B,GJA3,ADRa1A,RGS16,RGS18,PKIG,CX35.4 |
| Cholinergic synapse | Adcy4,BCL2,CREB5,CAMK2A,CHRNA7,GNA11,PLCB3,PRKCA,GNAI3,CHRNB4 |
| G alpha (q) signalling events | OPN4,FPR-RS4,LPAR2B,UTS2D,CCK,KALRNB,TRPC3,FPR-RS6,EDN1,APPA |
Protein Function
CHRM1 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity,drug binding,phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM1 itself. We selected most functions CHRM1 had, and list some proteins which have the same functions with CHRM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol phospholipase C activity | PLCD4,PLCD3A,PLCH2,PLCB3,PLCB1,PLCH1,PLCG2,CCKBR,PLCG1,PLCZ1 |
| G-protein coupled acetylcholine receptor activity | CHRM3,CHRM5B,CHRM4,CHRM5,CHRM2A,CHRM2,CHRM5A |
| drug binding | DAAM2,ACE,CYP4B1,TLR7,GRIK1,HTR2B,DRD4,PIGC,ADRB2,DCK |
Interacting Protein
CHRM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM1.
Dlg4;GPRASP1;GPRASP2;pirenzepine/gastrozepin;ARRB2;ARRB1
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