CHRFAM7A
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Official Full Name
CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -
Overview
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. -
Synonyms
CHRFAM7A;CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion;CHRNA7-FAM7A fusion protein;CHRNA7 DR1;D 10;Alpha 7 neuronal nicotinic acetylcholine receptor FAM7A hybrid;CHRNA7 (cholinergic receptor nicotinic alpha 7 exons 5 10) and FAM7A (family with sequence similarity 7A exons A E) fusion;CHRNA7;CHRNA7 FAM7A fusion;CHRNA7 FAM7A fusion protein;D10;HGNC:15781;MGC120482;MGC120483;alpha-7 nicotinic cholinergic receptor subunit;alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid;CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion;D-10;CHRNA7-DR1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHRFAM7A-11204H | Recombinant Human CHRFAM7A, His-tagged | E.coli | Human | His | 241-386a.a. | |
| CHRFAM7A-7522HCL | Recombinant Human CHRFAM7A 293 Cell Lysate | HEK293 | Human | Non |
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| RFL35474HF | Recombinant Full Length Human Chrna7-Fam7A Fusion Protein(Chrfam7A) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-412) |
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Involved Pathway
CHRFAM7A involved in several pathways and played different roles in them. We selected most pathways CHRFAM7A participated on our site, such as SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRFAM7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | LMX1B,PKNOX1,SCN3B,MAP2,EN1,RUNX3,SST,TPH2,SP3,CC2D1A |
Protein Function
CHRFAM7A has several biochemical functions, for example, acetylcholine binding,contributes_to acetylcholine receptor activity,contributes_to acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRFAM7A itself. We selected most functions CHRFAM7A had, and list some proteins which have the same functions with CHRFAM7A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to acetylcholine receptor activity | ZACN,CHRNA4B,CHRNB1,CHRNA10A,CHRNB1L,CHRNA10,CHRNB3B,CHRNA9,CHRND,CHRNA2A |
| contributes_to acetylcholine-activated cation-selective channel activity | CHRNA1,CHRNB3B,CHRNB3A,CHRNB1,CHRNA10,CHRNA2A,CHRNA4B,CHRNA10A,CHRNB1L,CHRNA9 |
| acetylcholine binding | ACHE,CHRNB3,CHRNA7,CHRNA3,CHRM3,CHRNA4,CHRNB1,CHRNB2 |
Interacting Protein
CHRFAM7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRFAM7A here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRFAM7A.
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