CHRDL2
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Official Full Name
Chordin-Like 2 -
Overview
CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors. -
Synonyms
CHRDL2;chordin-like 2;BNF1;CHL2;FKSG37;DKFZp586N2124;chordin-like protein 2;BNF-1;chordin-related protein 2;breast tumor novel factor 1;OTTHUMP00000230490;OTTHUMP00000230491;OTTHUMP00000230494
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293
- HEK293T
- His
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CHRDL2 involved in several pathways and played different roles in them. We selected most pathways CHRDL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRDL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CHRDL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRDL2 itself. We selected most functions CHRDL2 had, and list some proteins which have the same functions with CHRDL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TSEN54,KRT33B,MAD2L2,UNC119B,TXNL4B,C9orf16,PAK3,CWC15,TNFAIP8L2,RIBC2 |
Interacting Protein
CHRDL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRDL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRDL2.
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