CHN2

  • Official Full Name

    chimerin (chimaerin) 2

  • Overview

    This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

  • Synonyms

    CHN2;chimerin (chimaerin) 2;beta-chimaerin;ARHGAP3;beta chimerin;RhoGAP3;beta-chimerin;beta3-chimaerin;rho-GTPase-activating protein 3;BCH;CHN2-3;MGC138360

Recombinant Proteins

  • Rat
  • Rhesus macaque
  • Human
  • Mouse
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    CHN2 involved in several pathways and played different roles in them. We selected most pathways CHN2 participated on our site, such as ErbB1 downstream signaling,Regulation of RAC1 activity,Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction KAL1,KLHL12,IFT122,RNF31,CLIP3,MLN,RSPO3,DNAL4B,KIF7,FABP11B
    ErbB1 downstream signaling ACTR2,ABI1,MAP3K2,BAIAP2,NCKAP1,EGR1,WASF2,ARF4,EPS8,ACTR3
    Regulation of RAC1 activity EPS8,ABR,SPATA13,CHN1,ARHGAP9,RAP1GDS1,DOCK6,DEF6,RALBP1,ARHGEF25
    Signaling by Rho GTPases ARHGAP29,NOXO1,NCKIPSD,STARD13,TAGAP1,RHOT1B,GDI2,ARHGAP33,ARHGAP1,ARHGAP17A
    Rho GTPase cycle PLEKHG2,ARHGAP28,RALBP1,GDI1,AKAP13,ARHGAP31,NET1,MCF2L,RHOV,FAM13B

    Protein Function

    CHN2 has several biochemical functions, for example, GTPase activator activity,SH3/SH2 adaptor activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHN2 itself. We selected most functions CHN2 had, and list some proteins which have the same functions with CHN2. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity GRB2,NCK2,PTPN11,SH3BGRL,GRB7,IRS4,RUSC1,GRAP,SLA2,CRK
    protein binding BRD3,NEK2,TOMM7,CDIPT,NUP85,ZNF410,COMP,MYL7,MCM8,SPINK7
    metal ion binding BMI1A,ZBTB16A,C2,TKT,ZNF296,ZNF488,AGAP2,CYP2B19,ZNF438,ATP2A1L
    GTPase activator activity ARHGAP11A,SRGAP3,ARHGAP40,DLC1,RIN1,ARFGAP1,RGS14A,ARHGDIA,ARHGDIG,ALS2CL

    Interacting Protein

    CHN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHN2.

    RAC1;ERBB3;RB1;BAG6;SUMO2;SMARCD1;TP53RK;RANBP3

    Resources

    References

    • Scharfstein, J; Schmitz, V; et al. Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B-2 receptors. JOURNAL OF EXPERIMENTAL MEDICINE 192:1289-1299(2000).
    • Yoshizaki, N; Yonezawa, S; et al. Cysteine proteinase plays a key role for the initiation of yolk digestion during development of Xenopus laevis. DEVELOPMENT GROWTH & DIFFERENTIATION 40:659-667(1998).

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