CHD8
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Official Full Name
chromodomain helicase DNA binding protein 8 -
Overview
CHD8 belongs to the chromodomain helicase DNA-binding (CHD) family of ATP-dependent chromatin remodeling proteins. The CHD family of proteins has been shown to play an important role in regulating gene expression by utilizing the energy derived from ATP h -
Synonyms
CHD8;chromodomain helicase DNA binding protein 8;helicase with SNF2 domain 1 , HELSNF1;chromodomain-helicase-DNA-binding protein 8;DUPLIN;KIAA1564;axis duplication inhibitor;ATP-dependent helicase CHD8;helicase with SNF2 domain 1;HELSNF1
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHD8-1217H | Recombinant Human CHD8 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CHD8-1366R | Recombinant Rat CHD8 Protein | Mammalian Cell | Rat | His |
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| CHD8-3383M | Recombinant Mouse CHD8 Protein | Mammalian Cell | Mouse | His |
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| CHD8-7974Z | Recombinant Zebrafish CHD8 | Mammalian Cell | Zebrafish | His |
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| CHD8-1024R | Recombinant Rat CHD8 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CHD8-1024R-B | Recombinant Rat CHD8 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CHD8-1635M | Recombinant Mouse CHD8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CHD8-1635M-B | Recombinant Mouse CHD8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CHD8-773H | Recombinant Human CHD8 Protein, His-tagged | E.coli | Human | His | Leu823-Arg1288 |
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Involved Pathway
CHD8 involved in several pathways and played different roles in them. We selected most pathways CHD8 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | PPP3R2,MAP3K7,FZD6,CAMK2D,LRP5,FBXW2,CAMK2B1,CER1,WNT2BA,NLK2 |
Protein Function
CHD8 has several biochemical functions, for example, ATP binding,DNA binding,DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHD8 itself. We selected most functions CHD8 had, and list some proteins which have the same functions with CHD8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-dependent ATPase activity | MSH5,SMARCA2,RAD51B,TTF2,RAD51D,CDK7,MSH6,DHX36,DMC1,SMARCAL1 |
| helicase activity | WRN,PEO1,CHD9,HELZ,HLTF,ZRANB3,BLM,DHX32A,UPF1,GTF2F2B |
| nucleotide binding | OXSR1A,ATP1A3B,DNAJC17,ABCB6,HUG,CAMKK1A,SCAF8,HSPA12A,ATP8B1,ORC5 |
| DNA helicase activity | RAD54B,MCM5,INO80,IGHMBP2,RECQL,SUPV3L1,RUVBL1,FBXO18,MCM6L,ATRX |
| histone binding | SPTY2D1,DAXX,CD1D,PRKCBB,MYSM1,RNF168,CTSL2,HIST1H4B,PIH1D1,NASP |
| hydrolase activity | ATP2A2A,DPYSL5A,ABHD14B,GTF2F2B,ATP1A1A.1,NUDT19,MCM3L,CTSSB.2,PLAUB,PRSS30 |
| methylated histone binding | ZMYND11,KDM4A,PHF8,UHRF1,ATRX,ING2,CBX4,LRWD1,MSH6,TP53BP1 |
| hydrolase activity, acting on acid anhydrides | SMARCA4A,CHD9 |
| protein binding | VASN,TUBA3D,MED17,IKBKB,EFCAB11,AK3,PIK3R2,CSNK2A1,UBE2M,OCLN |
Interacting Protein
CHD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHD8.
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