CERS2
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Official Full Name
ceramide synthase 2 -
Overview
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. -
Synonyms
LAG1 homolog, ceramide synthase 2;LAG1 longevity assurance homolog 2 (S. cerevisiae);SP260;MGC987;CerS2;OTTHUMP00000033029;FLJ10243;OTTHUMP00000033030;L3;OTTHUMP00000033031;longevity assurance (LAG1, S. cerevisiae) homolog 2;ceramide synthase 2;Tumor metastasis-suppressor gene 1 protein;LAG1 longevity assurance 2;TMSG1;LAG1 longevity assurance homolog 2;LASS2;OTTHUMP00000033028;CERS2 ceramide synthase 2
Recombinant Proteins
- Human
- Mouse
- Bovine
- Mus musculus
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- E.coli expression system
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
CERS2 involved in several pathways and played different roles in them. We selected most pathways CERS2 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CERS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | SCP2,PAH,POLR2G,IDH2,FBP1,GGT5,PLCG2,MTHFD2,GAMT,IDUA |
| Sphingolipid signaling pathway | PLCB2,SPHK2,PPP2R2C,MAPK11,SPTLC2,SGPP2,LOC100328615,PPP2CA,PDPK1,PRKCB |
| Sphingolipid metabolism | SMPD2,ARSI,SPTLC2A,LASS4,SGMS2,ARSH,CERS4A,SPTLC1,FA2H,GDF1 |
Protein Function
CERS2 has several biochemical functions, for example, DNA binding,protein binding,sphingosine N-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CERS2 itself. We selected most functions CERS2 had, and list some proteins which have the same functions with CERS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingosine N-acyltransferase activity | FAM57B,LASS5,LASS1,CERS3B,CERS2A,CERS5,CERS4,LASS4,LASS2,CERS4A |
| protein binding | FAM53C,TLK2,CHEK2,HTR3E,RPL36AL,H3F3A,SUCLA2,SNAPC5,SLAMF7,TPI1 |
| DNA binding | LMX1BA,TERFA,MECP2,TCF25,KAT6B,HNRNPU,STRA13,SSH2,FOSL1A,FOXN1 |
Interacting Protein
CERS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CERS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CERS2.
SLC22A1;ASGR1;ASGR2;ATP6V0C;HSP90AA1;7242199;PSMD14;KIF1B;GABBR2;ARHGEF7;NDN
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