CELF4
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Official Full Name
CUGBP, Elav-like family member 4 -
Overview
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CELF4;CUGBP, Elav-like family member 4;Bruno (Drosophila) like 4, RNA binding protein , bruno like 4, RNA binding protein (Drosophila) , BRUNOL4;CUGBP Elav-like family member 4;Bruno like protein 4;bruno like 4, RNA binding protein;Bruno like 4, RNA binding protein (Drosophila);BRUNOL 4;CELF 4;CUG BPand ETR 3 like factor 4;CUGBP, Elav like family member 4;LYST interacting protein LIP9;RNA binding protein BRUNOL 4;RNA binding protein BRUNOL4;CELF-4;bruno-like protein 4;RNA-binding protein BRUNOL4;RNA-binding protein BRUNOL-4;LYST-interacting protein LIP9;CUG-BP and ETR-3 like factor 4;CUG-BP- and ETR-3-like factor 4;bruno-like 4, RNA binding protein;Bruno -like 4, RNA binding protein;BRUNOL4;BRUNOL-4
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CELF4-3275M | Recombinant Mouse CELF4 Protein | Mammalian Cell | Mouse | His |
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| CELF4-352H | Recombinant Human CELF4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CELF4-683Z | Recombinant Zebrafish CELF4 | Mammalian Cell | Zebrafish | His |
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| CELF4-183HCL | Recombinant Human CELF4 cell lysate | Human | Non |
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| CELF4-1570M | Recombinant Mouse CELF4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CELF4-1570M-B | Recombinant Mouse CELF4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CELF4-3815HF | Recombinant Full Length Human CELF4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 250 amino acids |
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Involved Pathway
CELF4 involved in several pathways and played different roles in them. We selected most pathways CELF4 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CELF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | SF3A3,PTBP1A,CLK3,EBI3,PRPF4B,D19BWG1357E,DHX15,PRMT2,HNRNPABA,ADAM5 |
Protein Function
CELF4 has several biochemical functions, for example, BRE binding,mRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CELF4 itself. We selected most functions CELF4 had, and list some proteins which have the same functions with CELF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| translation repressor activity, nucleic acid binding | CPEB1B,CPEB2,CPEB1A,CPEB3,PAIP2B,CELF1,CPEB4,PURA,PPP1R2P9,CPEB1 |
| nucleotide binding | RBMY1F,TUBA8L2,ABCA5,MYO5A,CLCN6,FHIT,MRPL39,WEE2,ATP2A2A,TSSK1 |
| BRE binding | CELF1 |
| mRNA binding | XPO5,TYMS,MRPS7,RBM25,RBFOX3,PARK7,EIF4ENIF1,DCP1B,SOSTDC1B,RPS26 |
Interacting Protein
CELF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CELF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CELF4.
Resources
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References
- Hinney, A; Albayrak, O; et al. Genetic Variation at the CELF1 (CUGBP, Elav-Like Family Member 1 Gene) Locus is Genome-Wide Associated With Alzheimer's Disease and Obesity. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 165:283-293(2014).
- Karunakaran, DKP; Congdon, S; et al. The expression analysis of Sfrs10 and Celf4 during mouse retinal development. GENE EXPRESSION PATTERNS 13:425-436(2013).
