CEA
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Official Full Name
Carcinoembryonic antigen -
Overview
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Therefore CEA is usually present only at very low levels in the blood of healthy adults. However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. Serum levels can also be elevated in heavy smokers. CEA are glycosyl phosphatidyl inositol (GPI) cell surface anchored glycoproteins whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells. Immunologically they are characterized as members of the CD66 cluster of differentiation. -
Synonyms
CEA;Carcinoembryonic antigen
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Involved Pathway
CEA involved in several pathways and played different roles in them. We selected most pathways CEA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CEA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CEA has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CEA itself. We selected most functions CEA had, and list some proteins which have the same functions with CEA. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
CEA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEA here. Most of them are supplied by our site. Hope this information will be useful for your research of CEA.
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References
- Guo, MD; Dong, J; et al. SERS tags-based novel monodispersed hollow gold nanospheres for highly sensitive immunoassay of CEA. JOURNAL OF MATERIALS SCIENCE 50:3329-3336(2015).
- de Jong, M; Van Laere, K; et al. Highlights lecture EANM 2014: "Gimme gimme gimme those nuclear Super Troupers". EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 42:781-802(2015).
