CDK19
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Official Full Name
cyclin-dependent kinase 19 -
Overview
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. -
Synonyms
CDK11;CDC2L6;KIAA1028;bA346C16.3;cyclin-dependent kinase 19;OTTHUMP00000017005;OTTHUMP00000017006;OTTHUMP00000017007;death-preventing kinase;cyclin-dependent kinase 11;CDC2-related protein kinase 6;cell division protein kinase 19;CDK8-like cyclin-dependent kinase;cyclin-dependent kinase (CDC2-like) 11;cell division cycle 2-like 6 (CDK8-like);cell division cycle 2-like protein kinase 6
Recombinant Proteins
- Human
- Mouse
- Sf9 Insect Cell
- Wheat Germ
- HEK293
- HEK293T
- Insect (sf21)
- In Vitro Cell Free System
- GST
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDK11B-1534H | Recombinant Human CDK11, Unactive, GST-tagged | Sf9 Insect Cell | Human | GST | Full length |
|
| CDK19-5145H | Recombinant Human CDK19 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| CDK19-7630HCL | Recombinant Human CDK19 293 Cell Lysate | HEK293 | Human | Non |
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| Cdk19-2087M | Recombinant Mouse Cdk19 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CDK19-2845HF | Active Recombinant Full Length Human CDK19 Protein, GST-tagged | Insect (sf21) | Human | GST | Full L. 1-502 |
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| CDK19-3778HF | Recombinant Full Length Human CDK19 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 502 amino acids |
|
| CDK19-4428H | Recombinant Human CDK19 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
CDK19 involved in several pathways and played different roles in them. We selected most pathways CDK19 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | AKAP5,NUDT11,MED20,COX14,SULT4A1,INSIG2,GPHNA,CRYM,SLC25A32A,COX16 |
| Developmental Biology | HIF3A,FRS2B,LIN28A,NRP2,CDK8,DUSP2,DUSP9,DUSP10,ACTR2B,FGF20A |
| PPARA activates gene expression | GRHL1,PLIN2,SREBF2,MED6,MED10,G0S2,MED29,MED22,MED31,APOA5 |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACAD11,SLC25A1A,ACOT8,ECI1,AGPAT2,GPAT2,ELOVL1A,ACOT9,MED15,ESRRA |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED9,MED26,MED10,CTGF,MED22,GRHL1,MED21,G0S2,MED6,MED18 |
| Metabolism of lipids and lipoproteins | FA2H,AKR1C4,FAAH2A,CPNE6,DGAT1B,TIAM2,NFYBA,GC,FAAH2,ACSF3 |
| Transcriptional regulation of white adipocyte differentiation | MED21,MED9,MED18,EBF1,NR2F2,MED19,MED22,MED29,EGR2 |
Protein Function
CDK19 has several biochemical functions, for example, ATP binding,cyclin-dependent protein serine/threonine kinase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK19 itself. We selected most functions CDK19 had, and list some proteins which have the same functions with CDK19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CSF1R,ATP1A1,PAPSS2B,ABCB6A,IPMK,MAP4K6,HSPA5,LIMK2,EGFRA,MTHFD1B |
| enzyme binding | TSPAN33,CBX1,POLB,CNTNAP2,BLZF1,HYAL2,SLC18A1,CAT,PDE4DIP,BIRC5 |
| cyclin-dependent protein serine/threonine kinase activity | CDK9,CDKL2,CCNK,CDK17,STK30,CDK3,CDKL1,CDK15,MOK,CDK11A |
Interacting Protein
CDK19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK19.
MED12;MED26;CCNC;MED13;MED10;MED9
Resources
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References
- Kuo, CN; Chen, CY; et al. Cell cycle regulation by bevacizumab in ARPE-19 human retinal pigment epithelial cells. MOLECULAR MEDICINE REPORTS 6:701-704(2012).
- Lotan, Y; Bagrodia, A; et al. Prospective Evaluation of a Molecular Marker Panel for Prediction of Recurrence and Cancer-specific Survival After Radical Cystectomy. EUROPEAN UROLOGY 64:465-471(2013).
