CDIPT
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Official Full Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase -
Overview
Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. -
Synonyms
CDIPT;CDP-diacylglycerol--inositol 3-phosphatidyltransferase;CDP diacylglycerol inositol 3 phosphatidyltransferase (phosphatidylinositol synthase);phosphatidylinositol synthase;PIS;PIS1;MGC1328;CDP diacylglycerol inositol 3 phosphatidyltransferase (phosphatidylinositol synthase);CDP diacylglycerol inositol 3 phosphatidyltransferase;PtdIns synthase;PI synthase
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Rhesus macaque
- Mus musculus
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CDIPT involved in several pathways and played different roles in them. We selected most pathways CDIPT participated on our site, such as 3-phosphoinositide biosynthesis,D-myo-inositol (1,4,5)-trisphosphate biosynthesis,Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDIPT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | OSBP,CYP2AD2,ARF3,MED9,PEMT,PTGR1,CPNE1,PPP1R2,HSD17B11,MED7 |
| Metabolic pathways | QPRT,GALNT3,PRIM2,ALDH9A1A.1,GALNT1,B3GNT4,GALNT10,POLR2J2,CYP19A1B,CBS |
| Glycerophospholipid biosynthesis | AWAT1,PEMT,CPNE3,SLC44A5B,BCHE,AWAT2,PLBD1,AGPAT2,STIL,CPNE7 |
| D-myo-inositol (1,4,5)-trisphosphate biosynthesis | PLCD3,PIP5KL1 |
| 3-phosphoinositide biosynthesis | PIP5KL1,FIG4,PIK3R6 |
| Glycerophospholipid metabolism | CDS2,PLA2G5,PLD4,PISD,CDS1,PLD1,PLA2G2D,PCYT1AB,CHATA,CEPT1 |
| Inositol phosphate metabolism | NUDT3A,PLD4,PIP4K2B,INPP4B,PI4KAA,PI4K2B,ITPKC,PI4KB,PLCE1,TPI1 |
| Metabolism | LMF2,CHST9,Sult2a2,MED15,SLC23A2,ARSJ,CYP3A7,SULT2ST1,PLBD1,COX7C |
Protein Function
CDIPT has several biochemical functions, for example, CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity,alcohol binding,carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDIPT itself. We selected most functions CDIPT had, and list some proteins which have the same functions with CDIPT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | PKD1L2,SBP,GALNT9,KRT1,CLEC18B,SIGLEC11,PRPS1,MRC2,CANX,ATRNL1 |
| protein binding | PRPS2,TERF2,CSNK1E,NGFRB,RPL10A,ULK2,ULK3,XAGE3,TJP1,DOK3 |
| diacylglycerol binding | UNC13B,RASGRP4,RASGRP3,UNC13A,RASGRP2,TRPC2,UNC13C,RASGRP1 |
| manganese ion binding | IMPA1,B4GALT1,PRIMPOL,ENDOU,GYLTL1B,PPM1B,PIM1,PPM1NB,FEN1,FAM20C |
| alcohol binding | DPM1 |
Interacting Protein
CDIPT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDIPT here. Most of them are supplied by our site. Hope this information will be useful for your research of CDIPT.
Resources
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References
- Fu, CZ; Wang, H; et al. Expression profiles and polymorphism analysis of CDIPT gene on Qinchuan cattle. ELECTRONIC JOURNAL OF BIOTECHNOLOGY 17:162-167(2014).
- Murphy, TR; Vihtelic, TS; et al. Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye. EXPERIMENTAL EYE RESEARCH 93:460-474(2011).
