CDCA2
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Official Full Name
cell division cycle associated 2 -
Overview
CDCA2 is a regulator of chromosome structure during mitosis. CDCA2 forms an essential complex with protein phosphatase PP1-gamma subunit 1 (PPP1CC) and is required for the recruitment of PP1 to chromatin. Knockdown of CDCA2 by RNAi causes large-scale cell death by apoptosis, as does overexpression of a dominant-negative mutant of the protein. -
Synonyms
CDCA2;cell division cycle associated 2;Repo-Man;cell division cycle-associated protein 2;recruits PP1 onto mitotic chromatin at anaphase protein;protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDCA2-11021H | Recombinant Human CDCA2, GST-tagged | E.coli | Human | GST | 512-863a.a. | |
| CDCA2-3154M | Recombinant Mouse CDCA2 Protein | Mammalian Cell | Mouse | His |
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| CDCA2-1495M | Recombinant Mouse CDCA2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CDCA2-1495M-B | Recombinant Mouse CDCA2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
CDCA2 involved in several pathways and played different roles in them. We selected most pathways CDCA2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CDCA2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CDCA2 itself. We selected most functions CDCA2 had, and list some proteins which have the same functions with CDCA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CDCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDCA2.
MBD4;PPP1CC;NUP153;PPP1CB;KPNB1;Nup98;Rcc1;Ranbp2
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References
- Kurtova, AV; Xiao, J; et al. Blocking PGE(2)-induced tumour repopulation abrogates bladder cancer chemoresistance. NATURE 517:209-U224(2015).
- Izumiyama, T; Minoshima, S; et al. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. GENE 511:202-217(2012).
