CDC5L
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Official Full Name
cell division cycle 5-like -
Overview
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008] -
Synonyms
CDC5L;cell division cycle 5-like;CDC5;CEF1;PCDC5RP;CDC5-LIKE;dJ319D22.1;cell division cycle 5-like protein;Cdc5-related protein;pombe cdc5-related protein;dJ319D22.1 (CDC5-like protein);CDC5 cell division cycle 5-like
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDC5L-11017H | Recombinant Human CDC5L, GST-tagged | E.coli | Human | GST | C-term-350a.a. | |
| CDC5L-0954H | Recombinant Human CDC5L Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CDC5L-11308Z | Recombinant Zebrafish CDC5L | Mammalian Cell | Zebrafish | His |
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| CDC5L-769R | Recombinant Rhesus monkey CDC5L Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CDC5L-7648HCL | Recombinant Human CDC5L 293 Cell Lysate | HEK293 | Human | Non |
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| Cdc5l-2079M | Recombinant Mouse Cdc5l Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CDC5L-3105HF | Recombinant Full Length Human CDC5L Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 802 amino acids |
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| CDC5L-595R | Recombinant Rhesus Macaque CDC5L Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CDC5L-595R-B | Recombinant Rhesus Macaque CDC5L Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| CDC5L-803H | Recombinant Human CDC5L Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
CDC5L involved in several pathways and played different roles in them. We selected most pathways CDC5L participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC5L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | SF3B5,RBMX,HSC70,EFTUD2,SMX5,PUF60A,SF3B3,SF3B2,FAM120B,SRSF3 |
Protein Function
CDC5L has several biochemical functions, for example, DNA binding,WD40-repeat domain binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC5L itself. We selected most functions CDC5L had, and list some proteins which have the same functions with CDC5L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TAL2,RAC3,DOK1,KIF1C,NCAPD2,TRMT112,PLK2,CARD11,PTPN11,UBAP2L |
| WD40-repeat domain binding | USP47,MYB |
| DNA binding | ZSCAN1,KDM5A,TAF1D,HIST2H2AA2,KDM1B,PGR,ATF4,KDM5BA,XRCC5,PHC3 |
| poly(A) RNA binding | MANF,HNRNPD,HNRNPA2B1,AHNAK,LIN28B,MECP2,CSNK1E,FASTKD1,RPL18A,MYO5A |
Interacting Protein
CDC5L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC5L here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC5L.
PLRG1;HNRNPM;TTF2;YWHAG;ORC2;GOLGA2
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References
- Ganesh, K; van Maldegem, F; et al. Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha. FEBS LETTERS 588:21-27(2014).
- Ganesh, K; Adam, S; et al. CTNNBL1 Is a Novel Nuclear Localization Sequence-binding Protein That Recognizes RNA-splicing Factors CDC5L and Prp31. JOURNAL OF BIOLOGICAL CHEMISTRY 286:17091-17102(2011).
- Conticello, SG; Ganesh, K; et al. Interaction between anti body-diversification enzyme AID and spliceosome-associated factor CTNNBL1. MOLECULAR CELL 31:474-484(2008).
- Ajuh, P; Kuster, B; et al. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. EMBO JOURNAL 19:6569-6581(2000).
