CDC45
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Official Full Name
cell division cycle 45 homolog (S. cerevisiae) -
Overview
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CDC45L;CDC45L2;PORC-PI-1;cell division control protein 45 homolog;human CDC45;OTTHUMP00000197247;OTTHUMP00000197248;CDC45-related protein;cell division cycle 45-like 2;CDC45 cell division cycle 45 homolog;CDC45;cell division cycle 45 homolog (S. cerevisiae)
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDC45-12563Z | Recombinant Zebrafish CDC45 | Mammalian Cell | Zebrafish | His |
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| CDC45-5135H | Recombinant Human CDC45 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CDC45-7649HCL | Recombinant Human CDC45 293 Cell Lysate | HEK293 | Human | Non |
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| CDC45-2085HFL | Recombinant Full Length Human CDC45 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| CDC45-3755HF | Recombinant Full Length Human CDC45 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 566 amino acids |
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| CDC45-556H | Recombinant Human CDC45 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| CDC45-556H-B | Recombinant Human CDC45 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| CDC45-768H | Recombinant Human CDC45 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Cdc45-857M | Recombinant Mouse Cdc45 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
CDC45 involved in several pathways and played different roles in them. We selected most pathways CDC45 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC45 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | GMNN,CSNK2A2,NDEL1,LIN37,GORASP1,CLASP1A,MAPRE1B,CEP152,FAM175A,NDEL1A |
Protein Function
CDC45 has several biochemical functions, for example, 3-5 DNA helicase activity,DNA replication origin binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC45 itself. We selected most functions CDC45 had, and list some proteins which have the same functions with CDC45. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | ANXA1,TTC6,CSDA,RAD51,TSN,PURB,HNRPDL,TDP2B,NEIL3,CNBPA |
| chromatin binding | HDAC2,TCF7,TPR,SETD7,URI1,HMGB1A,CHD7,HMGXB4A,FABP1,TRP53 |
| 3-5 DNA helicase activity | FBXO18,GINS1,WRN,ERCC3 |
| DNA replication origin binding | ORC3L,MCM2,MCM10,ORC4,ORC2L,HSPD1,MCM5,ORC4L |
| protein binding | RTDR1,LHX9,MMP20,STRAP,ACSS1,AHSA1,BBS7,PLXNC1,BARHL2,C3orf52 |
Interacting Protein
CDC45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC45 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC45.
CDKN1A;RPA2;CLSPN;CEP55;TOPBP1;ORC5
Resources
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References
- Takaya, J; Kusunoki, S; et al. Protein interaction and cellular localization of human CDC45. JOURNAL OF BIOCHEMISTRY 153:381-388(2013).
- Nagahama, Y; Ueno, M; et al. PSF3 marks malignant colon cancer and has a role in cancer cell proliferation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 392:150-154(2010).
