CDC42EP4
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Official Full Name
CDC42 effector protein (Rho GTPase binding) 4 -
Overview
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. -
Synonyms
CDC42EP4;CDC42 effector protein (Rho GTPase binding) 4;cdc42 effector protein 4;binder of Rho GTPases 4;BORG4;CEP4;KAIA1777;MGC3740;MGC17125;BORG4_HUMAN
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293T
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDC42EP4-0949H | Recombinant Human CDC42EP4 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CDC42EP4-766R | Recombinant Rhesus monkey CDC42EP4 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CDC42EP4-323HCL | Recombinant Human CDC42EP4 cell lysate | Human | Non |
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| Cdc42ep4-2077M | Recombinant Mouse Cdc42ep4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CDC42EP4-2299H | Recombinant Human CDC42EP4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| CDC42EP4-3104HF | Recombinant Full Length Human CDC42EP4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 356 amino acids |
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| CDC42EP4-3122H | Recombinant Human CDC42EP4 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CDC42EP4-592R | Recombinant Rhesus Macaque CDC42EP4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CDC42EP4-592R-B | Recombinant Rhesus Macaque CDC42EP4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CDC42EP4 involved in several pathways and played different roles in them. We selected most pathways CDC42EP4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42EP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CDC42EP4 has several biochemical functions, for example, GTP-Rho binding,GTPase activator activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42EP4 itself. We selected most functions CDC42EP4 had, and list some proteins which have the same functions with CDC42EP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ARSA,MID1,EAF1,PDE3B,ANKZF1,TRAP1,TDG,FBXW7,PDCD4,IL1RL1 |
| GTP-Rho binding | TNFAIP1,CDC42EP5,KCTD13,CDC42EP1B,EXOC1,WHAMM,ROCK2A,ROCK2B,NET1,PKN1 |
| GTPase activator activity | RGS12,SRGAP1,ARHGAP4,ARRB1,ARHGAP20,ARHGAP8,TBC1D10B,RALGAPA2,RABGAP1L,RGS5B |
| poly(A) RNA binding | POP7,RPL32,TARDBP,FXR2,HIST1H1E,YTHDC1,PKM2,KIAA1967,PPIG,PTRH1 |
Interacting Protein
CDC42EP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42EP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42EP4.
FAM9B;SRPK2;SRPK1;PA;CDC42;WDR6;Sept7;Sept2;Sept9;Kctd5
Resources
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References
- Abolghait, SK; Iida, T; et al. Recombinant AexU effector protein of Aeromonas veronii bv. sobria disrupts the actin cytoskeleton by downregulation of Rac1 and induces direct cytotoxicity to beta 4-integrin expressing cell lines. MICROBIAL PATHOGENESIS 51:454-465(2011).
- Wang, YQ; Ohkubo, T; et al. Enhanced cell-substratum adhesion of E-cadherin-expressing cells is mediated by activation of the small GTPase protein, Rac1. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 17:637-642(2006).
