CDC14B
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Official Full Name
CDC14 cell division cycle 14 homolog B (S. cerevisiae) -
Overview
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. -
Synonyms
CDC14B;CDC14 cell division cycle 14 homolog B (S. cerevisiae);dual specificity protein phosphatase CDC14B;Cdc 14B;Cdc 14B1;Cdc 14B2;CDC 14B3;CDC14 cell division cycle 14 homolog B;CDC14 homolog B;Cdc14B1;Cdc14B2;CDC14B3;Cell division cycle 14 homolog B;hCDC 14B;hCDC14B;OTTHUMP00000063774
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDC14B-0900H | Recombinant Human CDC14B Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CDC14B-10525Z | Recombinant Zebrafish CDC14B | Mammalian Cells | Zebrafish | His |
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| CDC14B-3127M | Recombinant Mouse CDC14B Protein | Mammalian Cells | Mouse | His |
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| CDC14B-318HCL | Recombinant Human CDC14B cell lysate | Human | Non |
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| CDC14B-1478M | Recombinant Mouse CDC14B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CDC14B-1478M-B | Recombinant Mouse CDC14B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CDC14B-3117HF | Recombinant Full Length Human CDC14B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 471 amino acids |
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Involved Pathway
CDC14B involved in several pathways and played different roles in them. We selected most pathways CDC14B participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC14B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CDC16,CDC25A,MYCB,CDK1,NDEL1B,TEX15,ANAPC13,FZR1A,CENPP,TUBB4A |
Protein Function
CDC14B has several biochemical functions, for example, protein binding,protein serine/threonine phosphatase activity,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC14B itself. We selected most functions CDC14B had, and list some proteins which have the same functions with CDC14B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase activity | PPM1AA,DUSP23B,PPEF2,ILKAP,DUSP23A,CTDNEP1B,PP2D1,CDC14A,CTDNEP1,PPM1J |
| protein binding | USP9X,NUPL1,DHX40,STK11,MUTED,AHCYL2,C16orf72,TGFA,SIAH1A,TNFRSF10A |
| protein tyrosine phosphatase activity | MTMR4,PTPREB,PTPN23,CDC14AB,CDC14AA,DUSP7,PALD1,DUSP2,CDC25A,DUSP28 |
| protein tyrosine/serine/threonine phosphatase activity | SGPP2,DUSP5,PTPRQ,DUSP11,DUSP10,PTENB,SSH2B,DUSP26,EYA3,PXYLP1 |
Interacting Protein
CDC14B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC14B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC14B.
SIRT2;FZR1;BUB1;BCL10;MCC;CCND1;MSH2;SMAD4;STK11;CDKN2A;DLC1;MLH3;npm_alk
Resources
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References
- Kim, Y; Choi, JW; et al. Loss of CDC14B Expression in Clear Cell Renal Cell Carcinoma Meta-Analysis of Microarray Data Sets. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 141:551-558(2014).
- Galeano, F; Rossetti, C; et al. ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis. ONCOGENE 32:998-1009(2013).
