CD46
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Official Full Name
CD46 molecule, complement regulatory protein -
Overview
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] -
Synonyms
CD46;CD46 molecule, complement regulatory protein;MCP;TLX;AHUS2;MIC10;TRA2.10;membrane cofactor protein;measles virus receptor;complement membrane cofactor protein;trophoblast leucocyte common antigen;trophoblast leukocyte common antigen;CD46 antigen, complement regulatory protein;trophoblast-lymphocyte cross-reactive antigen;antigen identified by monoclonal antibody TRA-2-10;membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
Recombinant Proteins
- Human
- Cynomolgus
- Canine
- Rat
- Mouse
- Rhesus macaque
- Guinea Pig
- Chlorocebus Aethiops
- Guinea pig
- Mus musculus
- Sus scrofa (Pig)
- Saguinus oedipus (Cotton-top tamarin)
- HEK293
- Mammalian cell
- C-His
- Wheat Germ
- Mammalian Cell
- E.coli
- Human Cell
- Human Cells
- In Vitro Cell Free System
- CHO
- Mammalian cells
- E.coli expression system
- His
- Fc
- Non
- GST
- His&GST
- His&Fc&Avi
Involved Pathway
CD46 involved in several pathways and played different roles in them. We selected most pathways CD46 participated on our site, such as Complement and coagulation cascades,Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Measles | IL12B,PIK3R3,CD3G,RELA,DOK1,IL2RA,STAT5B,OAS2,CD209B,IFNA4 |
| Complement and coagulation cascades | F13B,C1S,PLAU,F12,SERPINA5,MASP1,F10,KNG1,PLG,MBL1 |
Protein Function
CD46 has several biochemical functions, for example, cadherin binding,complement binding,endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD46 itself. We selected most functions CD46 had, and list some proteins which have the same functions with CD46. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| virus receptor activity | HAVCR1,IDE,SLAMF1,HYAL2,CLEC4G,ITGB3,SCARB2,PVRL2,SIVA1,ICAM1 |
| receptor activity | MED16,KIR2DL1,TLR3,LYVE1,GRIN1A,GRIN3B,ITGAX,NOTCH1,NRXN3,SLC20A1 |
| cadherin binding | AKAP5,MMP24,FER,JUPA,VCL,CDH13,FXYD5,CTNNA2,Fert2,CD2AP |
| endopeptidase activity | HTRA4,MMP1A,ATG4B,PSMA7,SENP1,FURIN,PCSK6,PSMB5,ADAMTS3,KLK1B22 |
| complement binding | C8G,CFB,CD59,CR2,C8A |
| protein binding | TSPYL4,POLH,SFRP5,FLII,SULT1B1,PKP2,CLK4,GPR3,SNCG,LAMTOR3 |
| enzyme inhibitor activity | SLN,PLN,FRY,PRPSAP1,TAE1,TXNIP,WDTC1,KIAA1967,APOV1,ARRB1 |
Interacting Protein
CD46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD46 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD46.
JAG1;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;C3;STK39;EBNA2;q8d1h5_yerpe;carA;toxA;toxB
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References
- Drager, C; Beer, M; et al. Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro. ARCHIVES OF VIROLOGY 160:739-746(2015).
- Scambi, C; Ugolini, S; et al. The Local Complement Activation on Vascular Bed of Patients with Systemic Sclerosis: A Hypothesis-Generating Study. PLOS ONE 10:-(2015).
